{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T21:07:55Z","timestamp":1775509675481,"version":"3.50.1"},"reference-count":87,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T00:00:00Z","timestamp":1683763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The management of pregnant women with thrombophilia and a history of gestational vascular complications remains debatable. Treatment of the latter is often based on clinical outcome rather than disease mechanism. While the use of venous thromboembolism prophylaxis in pregnancy is recommended for those at increased risk, the ability of anticoagulant and\/or antiplatelet agents to lower the risk of placenta\u2010mediated complications in this clinical setting remains controversial. The available guidelines are inconsistent in some situations, which reflects the limited evidence base. This review critically discusses risk assessment models (RAMs) and management strategies of women with thrombophilia and pregnancy complications, using clinical vignettes. RAMs, taking into account obstetric and thrombotic history as well as thrombophilia status, could drive a precision medicine approach, based on disease mechanism, and guide individual therapeutic interventions in high\u2010risk clinical settings.<\/jats:p>","DOI":"10.1111\/bjh.18856","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T23:49:46Z","timestamp":1683848986000},"page":"18-30","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Assessment\u2010based management of placenta\u2010mediated pregnancy complications: Pragmatism until a precision medicine approach evolves"],"prefix":"10.1111","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3139-085X","authenticated-orcid":false,"given":"Benjamin","family":"Brenner","sequence":"first","affiliation":[{"name":"Department of Hematology Rambam Health Care Campus  Haifa Israel"},{"name":"Ruth and Bruce Rappaport Faculty of Medicine Technion  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanouil","family":"Papadakis","sequence":"additional","affiliation":[{"name":"Thrombosis &amp; Hemostasis Clinic, Ob\/Gyn Hematology Genesis Hospital  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian A.","family":"Greer","sequence":"additional","affiliation":[{"name":"Queen's University Belfast  Belfast UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9899-9910","authenticated-orcid":false,"given":"Jean\u2010Christophe","family":"Gris","sequence":"additional","affiliation":[{"name":"Department of Haematology, CHU N\u00eemes University of Montpellier  N\u00eemes France"},{"name":"UMR UA11 INSERM IDESP\u2014Montpellier University  Montpellier France"},{"name":"Department of Obstetrics, Gynaecology and Perinatal Medicine I.M. Sechenov First Moscow State Medical University  Moscow Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1521-6926(02)00099-3"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1986.tb07830.x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2011.07.025"},{"key":"e_1_2_12_5_1","first-page":"345","article-title":"Disorders of placental villous maturation in fetal death","volume":"48","author":"Jaiman S","year":"2020","journal-title":"J Perinat Med"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.14345"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.11.015"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2022.04.015"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)04125-6"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12813"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2002.810507.x"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2008.11.001"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2010.01.012"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/652796"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-014-1111-6"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/157483"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1668524"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i6253"},{"key":"e_1_2_12_19_1","unstructured":"The Royal College of Obstetricians and Gynaecologists.Reducing the risk of thrombosis and embolism during pregnancy and the puerperium (green\u2010top guideline no. 37a).2015[cited 2023 May 7]. Available from:https:\/\/www.rcog.org.uk\/guidance\/browse\u2010all\u2010guidance\/green\u2010top\u2010guidelines\/reducing\u2010the\u2010risk\u2010of\u2010thrombosis\u2010and\u2010embolism\u2010during\u2010pregnancy\u2010and\u2010the\u2010puerperium\u2010green\u2010top\u2010guideline\u2010no\u201037a\/"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69204-0"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001703-199412000-00006"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12771-7"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12959-016-0118-9"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2300"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018024802"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2022-171707"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-703728"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-01-0149"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2016.06.001"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01307.x"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06317.x"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14452"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.0000.d01-1465.x"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1000641"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.080763"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-2062"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-267252"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31139-4"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-3-69"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.03.048"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH10-05-0334"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-12-626739"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-015-0719-9"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2020.03.015"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1184-8388"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.06.044"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(91)90379-6"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.120280"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100789"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2015.09.021"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.09.023"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000188979.74172.4d"},{"issue":"4","key":"e_1_2_12_53_1","first-page":"428","article-title":"Familial thrombophilia and the occurrence of fetal growth restriction","volume":"86","author":"Martinelli P","year":"2001","journal-title":"Haematologica"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.09.011"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901073400102"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)70025-0"},{"issue":"7","key":"e_1_2_12_57_1","first-page":"785","article-title":"Thrombophilic mutations are a main risk factor for placental abruption","volume":"88","author":"Facchinetti F","year":"2003","journal-title":"Haematologica"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2012.04773.x"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004659.pub3"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1159\/000341264"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.7326\/M13-2844"},{"key":"e_1_2_12_62_1","volume-title":"Hypertension in pregnancy: the management of hypertensive disorders during pregnancy","author":"National Collaborating Centre for Women's and Children's Health (UK)","year":"2010"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000149950.05182.a3"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1159\/000336662"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04553.x"},{"issue":"6","key":"e_1_2_12_66_1","first-page":"1053","article-title":"Addition of enoxaparin to aspirin for the secondary prevention of placental vascular complications in women with severe pre\u2010eclampsia. The pilot randomised controlled NOH\u2010PE trial","volume":"106","author":"Gris JC","year":"2011","journal-title":"Thromb Haemost"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60793-5"},{"issue":"4","key":"e_1_2_12_68_1","first-page":"771","article-title":"Enoxaparin for the secondary prevention of placental vascular complications in women with abruptio placentae. The pilot randomised controlled NOH\u2010AP trial","volume":"104","author":"Gris JC","year":"2010","journal-title":"Thromb Haemost"},{"issue":"7","key":"e_1_2_12_69_1","article-title":"Antithrombotic therapy for improving maternal or infant health outcomes in women considered at risk of placental dysfunction","author":"Dodd JM","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.11.006"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-021-01038-2"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.012877"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker139"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(96)00200-9"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1614217"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-021-08915-9"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2021.102901"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-018-1745-2"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209770"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01185.x"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203312451335"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2020.10.001"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2013.10.005"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1722225"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00109.2020"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2017.46"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719118766265"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deab153"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.18856","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T10:32:13Z","timestamp":1699612333000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.18856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,11]]},"references-count":87,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1111\/bjh.18856"],"URL":"https:\/\/doi.org\/10.1111\/bjh.18856","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,11]]},"assertion":[{"value":"2023-02-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}