{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:14:07Z","timestamp":1785795247564,"version":"3.56.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T00:00:00Z","timestamp":1684108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009210","name":"Food and Drug Administration","doi-asserted-by":"publisher","award":["FD006030"],"award-info":[{"award-number":["FD006030"]}],"id":[{"id":"10.13039\/100009210","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We explored the association of novel urinary biomarkers with albumin\u2010creatinine ratio (ACR) in adults with sickle cell anaemia. Of 37 participants, 13 (35.2%) had persistent albuminuria (PA). Urinary levels of clusterin (<jats:italic>p<\/jats:italic>\u2009=\u20090.002), retinol\u2010binding protein 4 (<jats:italic>p<\/jats:italic>\u2009=\u20090.008), alpha\u20101 microglobulin (<jats:italic>p<\/jats:italic>\u2009=\u20090.002) and angiotensinogen (<jats:italic>p<\/jats:italic>\u2009=\u20090.006) were significantly higher in participants with PA than in those without PA. Although univariate analysis showed significant associations between both alpha\u20101 microglobulin (<jats:italic>p<\/jats:italic>\u2009=\u20090.035) and angiotensinogen (<jats:italic>p<\/jats:italic>\u2009=\u20090.0021) with ACR, only angiotensinogen was associated with ACR in multivariable analysis (<jats:italic>p<\/jats:italic>\u2009=\u20090.04). Our results suggest that urinary angiotensinogen may identify sickle cell anaemia patients at risk for kidney disease.<\/jats:p>","DOI":"10.1111\/bjh.18862","type":"journal-article","created":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T04:32:29Z","timestamp":1684211549000},"page":"669-673","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Urinary angiotensinogen is associated with albuminuria in adults with sickle cell anaemia"],"prefix":"10.1111","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6088-0332","authenticated-orcid":false,"given":"Laila","family":"Elsherif","sequence":"first","affiliation":[{"name":"Center for Sickle Cell Disease University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praghalathan","family":"Kanthakumar","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Tennessee Health Scienter Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremiah","family":"Afolabi","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Tennessee Health Scienter Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley F.","family":"Stratton","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4662-1414","authenticated-orcid":false,"given":"Ugochi","family":"Ogu","sequence":"additional","affiliation":[{"name":"Center for Sickle Cell Disease University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marquita","family":"Nelson","sequence":"additional","affiliation":[{"name":"Center for Sickle Cell Disease University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayesha","family":"Mukhopadhyay","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Biostatistics and Environmental Health The University of Memphis  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1366-9267","authenticated-orcid":false,"given":"Matthew P.","family":"Smeltzer","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Biostatistics and Environmental Health The University of Memphis  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adebowale","family":"Adebiyi","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Tennessee Health Scienter Center  Memphis Tennessee 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