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Here, we present the first case of long\u2010term complete remission (CR) induced by influenza A (IAV, H1N1 subtype) in a refractory AML patient and have functionally validated this finding in two different animal disease models. We observed a significant increase in the proportion of helper T cells in the patient after IAV infection. The levels of cytokines, including IL\u20102, IL\u20104, IL\u20106, IL\u201010, IL\u201017A, IFN\u2010\u03b3 and TNF\u2010\u03b1, were higher in IAV\u2010infected patients compared with control groups. These findings indicate that the anti\u2010tumour effects induced by IAV are closely related to the modification of the immune response. Our study provides new evidence of the anti\u2010tumour effects of IAV from a clinical practice perspective.<\/jats:p>","DOI":"10.1111\/bjh.18876","type":"journal-article","created":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T01:24:02Z","timestamp":1685064242000},"page":"745-748","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Influenza A (H1N1) virus induced long\u2010term remission in a refractory acute myeloid leukaemia"],"prefix":"10.1111","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4575-3287","authenticated-orcid":false,"given":"Liangshun","family":"You","sequence":"first","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang P.R. China"},{"name":"Zhejiang Province Key Laboratory of Hematopoietic Malignancy Zhejiang University  Hangzhou Zhejiang P.R. 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