{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:08:52Z","timestamp":1790770132760,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T00:00:00Z","timestamp":1684886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81720108002"],"award-info":[{"award-number":["81720108002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2018ZX09734007"],"award-info":[{"award-number":["2018ZX09734007"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Lymphocyte proliferation and tumourigenesis are dependent on nucleotide synthesis to support DNA, RNA and phospholipid synthesis. Here, we identified that reprogramming of nucleotide metabolism as an important factor divides mantle cell lymphoma (MCL) into two groups with different transcriptional signalling pathways and varying prognoses. We establish a nucleotide metabolism\u2010related prognostic model that includes six genes with different regression coefficients, which significantly predicts prognosis for MCL patients (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). Of these six genes, de novo CTP synthesis pathway enzyme CTPS1 whose inhibitor (STP938) is already in clinical trials for relapsed\/refractory lymphomas (NCT05463263) has the highest regression coefficient. An increase in CTPS1 expression predicts adverse overall survival and progression\u2010free survival with independent prognostic significance in 105 primary MCL samples and GEO database (GSE93291). CRISPR CTPS1 knockout causes DNA damage and proliferation defects in MCL. Additionally, MYC positively regulates CTPS1 expression, and TP53\u2010aberrant and ibrutinib\u2010resistant MCL cells also rely on cytidine metabolism. Furthermore, besides the obvious decreased CTP pool caused by CTPS1 deficiency, CTPS1 inhibition may also induce immune\u2010related responses via activating dsDNA\u2010cGAS\u2010STING pathway, which plays a crucial role in impeding tumour growth in MCL patients.\n                  <\/jats:p>","DOI":"10.1111\/bjh.18878","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T02:03:35Z","timestamp":1684980215000},"page":"550-565","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["<scp>MYC<\/scp>\n                    \u2010induced cytidine metabolism regulates survival and drug resistance via\n                    <scp>cGas\u2010STING<\/scp>\n                    pathway in mantle cell lymphoma"],"prefix":"10.1111","volume":"202","author":[{"given":"Jin\u2010Hua","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"},{"name":"Key Laboratory of Hematology of Nanjing Medical University  Nanjing China"},{"name":"Collaborative Innovation Center for Cancer Personalized Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Min","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"},{"name":"Key Laboratory of Hematology of Nanjing Medical University  Nanjing China"},{"name":"Collaborative Innovation Center for Cancer Personalized Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai\u2010Xin","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"},{"name":"Key Laboratory of Hematology of Nanjing Medical University  Nanjing China"},{"name":"Collaborative Innovation Center for Cancer Personalized Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism The First Affiliated Hospital of Nanjing Medical University  Nanjing China"},{"name":"Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi\u2010Wen","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"},{"name":"Key Laboratory of Hematology of Nanjing Medical University  Nanjing China"},{"name":"Collaborative Innovation Center for Cancer Personalized Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010Ran","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"},{"name":"Key Laboratory of Hematology of Nanjing Medical University  Nanjing China"},{"name":"Collaborative Innovation Center for Cancer Personalized Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong\u2010Yao","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"},{"name":"Key Laboratory of Hematology of Nanjing Medical University  Nanjing China"},{"name":"Collaborative Innovation Center for Cancer Personalized Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Ting","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"},{"name":"Key Laboratory of Hematology of Nanjing Medical University  Nanjing China"},{"name":"Collaborative Innovation Center for Cancer Personalized Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"},{"name":"Key Laboratory of Hematology of Nanjing Medical University  Nanjing China"},{"name":"Collaborative Innovation Center for Cancer Personalized Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"},{"name":"Key Laboratory of Hematology of Nanjing Medical University  Nanjing China"},{"name":"Collaborative Innovation Center for Cancer Personalized Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"},{"name":"Key Laboratory of Hematology of Nanjing Medical University  Nanjing China"},{"name":"Collaborative Innovation Center for Cancer Personalized Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Yong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"},{"name":"Key Laboratory of Hematology of Nanjing Medical University  Nanjing China"},{"name":"Collaborative Innovation Center for Cancer Personalized Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4208-7477","authenticated-orcid":false,"given":"Wei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"},{"name":"Key Laboratory of Hematology of Nanjing Medical University  Nanjing China"},{"name":"Collaborative Innovation Center for Cancer Personalized Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,24]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.12.039"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-015-2070-4"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.12.006"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25204831"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-021-1999-2"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-22-0917"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2202672"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26523"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aau4972"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.02.005"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2022.07.011"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2022.215837"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-19-0650"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1107\/S1744309106018136"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/0-306-46843-3_50"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01530-21"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2022.07.003"},{"issue":"11","key":"e_1_2_12_19_1","first-page":"3107","article-title":"Cytidine 5\u2032\u2010triphosphate synthetase as a target for inhibition by the antitumor agent 3\u2010deazauridine","volume":"34","author":"McPartland RP","year":"1974","journal-title":"Cancer Res"},{"issue":"15","key":"e_1_2_12_20_1","first-page":"4347","article-title":"Expression of phosphorylated histone H2AX as a surrogate of cell killing by drugs that create DNA double\u2010strand breaks","volume":"63","author":"Banath JP","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20180139"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32335"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI139333"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-19-0761"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13386"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/271071a0"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.133880"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-21-1707"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2022.2105084"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-021-03206-5"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-22-0302"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.11.6.14670"},{"issue":"2","key":"e_1_2_12_33_1","first-page":"915","article-title":"Identification of critical genes associated with human osteosarcoma metastasis based on integrated gene expression profiling","volume":"20","author":"Fan H","year":"2019","journal-title":"Mol Med Rep"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1306220"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv111"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aau1167"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1025632"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.02321"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2022.2131407"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-022-01020-9"},{"key":"e_1_2_12_41_1","first-page":"1","article-title":"New directions for mantle cell lymphoma in 2022","volume":"42","author":"Kumar A","year":"2022","journal-title":"Am Soc Clin Oncol Educ Book"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-18-1020"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.18878","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T21:19:00Z","timestamp":1692220740000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.18878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,24]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/bjh.18878"],"URL":"https:\/\/doi.org\/10.1111\/bjh.18878","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,24]]},"assertion":[{"value":"2023-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}