{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:01:42Z","timestamp":1791331302764,"version":"4.3.1"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T00:00:00Z","timestamp":1684886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["RC\u20102023\u20102778890"],"award-info":[{"award-number":["RC\u20102023\u20102778890"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:italic>NPM1<\/jats:italic>\u2010mutated acute myeloid leukaemia (<jats:italic>NPM1<\/jats:italic><jats:sup>mut<\/jats:sup> AML) represents a mostly favourable\/intermediate risk disease that benefits from allogeneic haematopoietic stem cell transplantation (HSCT) in case of measurable residual disease (MRD) relapse or persistence after induction chemotherapy. Although the negative prognostic role of pre\u2010HSCT MRD is established, no recommendations are available for the management of peri\u2010transplant molecular failure (MF). Based on the efficacy data of venetoclax (VEN)\u2010based treatment in <jats:italic>NPM1<\/jats:italic><jats:sup>mut<\/jats:sup> AML older patients, we retrospectively analysed the off\u2010label combination of VEN plus azacitidine (AZA) as bridge\u2010to\u2010transplant strategy in 11 <jats:italic>NPM1<\/jats:italic><jats:sup>mut<\/jats:sup> MRD\u2010positive fit AML patients. Patients were in MRD\u2010positive complete remission (CR<jats:sub>MRDpos<\/jats:sub>) at the time of treatment: nine in molecular relapse and two in molecular persistence. After a median number of two cycles (range 1\u20134) of VEN\u2013AZA, 9\/11 (81.8%) achieved CR<jats:sub>MRD<\/jats:sub>\u2010negative (CR<jats:sub>MRDneg<\/jats:sub>). All 11 patients proceeded to HSCT. With a median follow\u2010up from treatment start of 26\u2009months, and a median post\u2010HSCT follow\u2010up of 19\u2009months, 10\/11 patients are alive (1 died from non\u2010relapse mortality), and 9\/10 patients are in MRD<jats:sub>neg<\/jats:sub> status. This patient series highlights the efficacy and safety of VEN\u2013AZA to prevent overt relapse, achieve deep responses and preserve patient fitness before HSCT, in patients with <jats:italic>NPM1<\/jats:italic><jats:sup>mut<\/jats:sup> AML in MF.<\/jats:p>","DOI":"10.1111\/bjh.18887","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T04:10:55Z","timestamp":1684987855000},"page":"599-607","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["A venetoclax and azacitidine <scp>bridge\u2010to\u2010transplant<\/scp> strategy for <i>NPM1<\/i>\u2010<scp>mutated<\/scp> acute myeloid leukaemia in molecular failure"],"prefix":"10.1111","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2356-5691","authenticated-orcid":false,"given":"C.","family":"Sartor","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Mediche e Chirurgiche Istituto di Ematologia \u201cSer\u00e0gnoli\u201d, Universit\u00e0 degli Studi di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Brunetti","sequence":"additional","affiliation":[{"name":"Clinica di Ematologia Azienda Ospedaliero\u2010Universitaria Ospedali Riuniti delle Marche  Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Audisio","sequence":"additional","affiliation":[{"name":"SC Ematologia, Dipartimento di Ematologia e Oncologia AO Citt\u00e0 della Salute e della Scienza di Torino  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Cignetti","sequence":"additional","affiliation":[{"name":"Department of Hematology and Cell Therapy A.O. 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