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We report results from a prospective study, PACE (Patients with AML and COVID\u201019 Epidemiology). 93 patients provided samples post\u2010vaccine 2 or 3 (PV2, PV3). Antibodies against SARS\u2010COV\u20102 spike antigen were detectable in all samples. Neutralization of the omicron variant was poorer than ancestral variants but improved PV3. In contrast, adequate T\u2010cell reactivity to SARS\u2010COV\u20102 spike protein was seen in only 16\/47 (34%) patients PV2 and 23\/52 (44%) PV3. Using regression models, disease response (not in CR\/Cri), and increasing age predicted poor T cell response.<\/jats:p>","DOI":"10.1111\/bjh.18894","type":"journal-article","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T07:10:31Z","timestamp":1686553831000},"page":"498-503","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Defective T\u2010cell response to <scp>COVID<\/scp>\u201019 vaccination in acute myeloid leukaemia and myelodysplastic syndromes"],"prefix":"10.1111","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0725-069X","authenticated-orcid":false,"given":"Justin","family":"Loke","sequence":"first","affiliation":[{"name":"Centre for Clinical Haematology Queen Elizabeth Hospital  Birmingham UK"},{"name":"CRUK Clinical Trials Unit University of Birmingham  Birmingham UK"},{"name":"Dana Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinit","family":"Upasani","sequence":"additional","affiliation":[{"name":"University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Gaskell","sequence":"additional","affiliation":[{"name":"CRUK Clinical Trials Unit University of Birmingham  Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Fox","sequence":"additional","affiliation":[{"name":"CRUK Clinical Trials Unit University of Birmingham  Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Fletcher","sequence":"additional","affiliation":[{"name":"CRUK Clinical Trials Unit University of Birmingham  Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Thomas","sequence":"additional","affiliation":[{"name":"CRUK Clinical Trials Unit University of Birmingham  Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Hopkins","sequence":"additional","affiliation":[{"name":"CRUK Clinical Trials Unit University of Birmingham  Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Kumari","sequence":"additional","affiliation":[{"name":"CRUK Clinical Trials Unit University of Birmingham  Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina","family":"Tang","sequence":"additional","affiliation":[{"name":"CRUK Clinical Trials Unit University of Birmingham  Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Yafai","sequence":"additional","affiliation":[{"name":"CRUK Clinical Trials Unit University of Birmingham  Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Boucher","sequence":"additional","affiliation":[{"name":"CRUK Clinical Trials Unit University of Birmingham  Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Homer","sequence":"additional","affiliation":[{"name":"CRUK Clinical Trials Unit University of Birmingham  Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arpad","family":"Toth","sequence":"additional","affiliation":[{"name":"Clatterbridge Cancer Hospital  Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. 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