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We and other groups have shown that GFI1 has a dose\u2010dependent role in the initiation, progression, and prognosis of acute myeloid leukaemia (AML) patients by inducing epigenetic changes. We now demonstrate a novel role for dose\u2010dependent GFI1 expression in regulating metabolism in haematopoietic progenitor and leukaemic cells. Using in\u2010vitro<\/jats:italic> and ex\u2010vivo<\/jats:italic> murine models of MLL::AF9<\/jats:italic>\u2010induced human AML and extra\u2010cellular flux assays, we now demonstrate that a lower GFI1<\/jats:italic> expression enhances oxidative phosphorylation rate via upregulation of the FOXO1\u2010 MYC axis. Our findings underscore the significance of therapeutic exploitation in GFI1<\/jats:italic>\u2010low\u2010expressing leukaemia cells by targeting oxidative phosphorylation and glutamine metabolism.<\/jats:p>","DOI":"10.1111\/bjh.18939","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T02:10:05Z","timestamp":1688955005000},"page":"1033-1048","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Dose\u2010dependent expression of GFI1<\/scp> alters metabolism in the haematopoietic progenitors and MLL<\/scp>::AF9<\/scp>\u2010induced leukaemic cells"],"prefix":"10.1111","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2605-4475","authenticated-orcid":false,"given":"Pradeep Kumar","family":"Patnana","sequence":"first","affiliation":[{"name":"Department of Medicine A, Hematology, Oncology and Pneumology University Hospital Muenster Muenster Germany"},{"name":"Department of 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