{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:29:31Z","timestamp":1790666971205,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:00:00Z","timestamp":1688083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Nodal peripheral T\u2010cell lymphoma (PTCL) with a T follicular helper phenotype (PTCL\u2010TFH) is a new type of PTCL. We aimed to define its clinical characteristics and prognosis compared to PTCL not otherwise specified (PTCL\u2010NOS) and angioimmunoblastic T\u2010cell lymphoma (AITL). This retrospective observational study included 175 patients diagnosed with PTCL between 2008 and 2013 in 13 Spanish sites. Patient diagnosis was centrally reviewed, and patients were reclassified according to the World Health Organization (WHO) 2016 criteria: 21 patients as PTCL\u2010NOS, 55 as AITL and 23 as PTCL\u2010TFH. Median follow\u2010up was 56.07\u2009months (95% CI 38.7\u201373.4). Progression\u2010free survival (PFS) and overall survival (OS) were significantly higher in patients with PTCL\u2010TFH than in those with PTCL\u2010NOS and AITL (PFS, 24.6\u2009months vs. 4.6 and 7.8\u2009months, respectively, <jats:italic>p<\/jats:italic>\u2009=\u20090.002; OS, 52.6\u2009months vs. 10.0 and 19.3\u2009months, respectively, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Histological diagnosis maintained an independent influence on both PFS (hazard ratio [HR] 4.1 vs. PTCL\u2010NOS, <jats:italic>p<\/jats:italic>\u2009=\u20090.008; HR 2.6 vs. AITL, <jats:italic>p<\/jats:italic>\u2009=\u20090.047) and OS (HR 5.7 vs. PTCL\u2010NOS, <jats:italic>p<\/jats:italic>\u2009=\u20090.004; HR 2.6 vs. AITL, <jats:italic>p<\/jats:italic>\u2009=\u20090.096), regardless of the International Prognostic Index. These results suggest that PTCL\u2010TFH could have more favourable features and prognosis than the other PTCL subtypes, although larger series are needed to corroborate these findings.<\/jats:p>","DOI":"10.1111\/bjh.18941","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T07:29:17Z","timestamp":1688110157000},"page":"182-193","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Peripheral T\u2010cell lymphoma with a T follicular\u2010helper phenotype: A different entity? Results of the Spanish <scp>Real\u2010T<\/scp> study"],"prefix":"10.1111","volume":"203","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6330-1028","authenticated-orcid":false,"given":"Alejandro","family":"Mart\u00edn\u00a0Garc\u00eda\u2010Sancho","sequence":"first","affiliation":[{"name":"Department of Hematology University Hospital of Salamanca (HUS\/IBSAL), CIBERONC, University of Salamanca and Cancer Research Institute of Salamanca\u2010IBMCC (USAL\u2010CSIC)  Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Socorro M.","family":"Rodr\u00edguez\u2010Pinilla","sequence":"additional","affiliation":[{"name":"Pathology Department Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz, CIBERONC  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Domingo\u2010Domenech","sequence":"additional","affiliation":[{"name":"Hematology Department Institut Catal\u00e0 d'Oncologia  L'Hospitalet de Llobregat Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fina","family":"Climent","sequence":"additional","affiliation":[{"name":"Pathology Department Hospital Universitari de Bellvitge\u2010IDIBELL  L'Hospitalet de Llobregat Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"S\u00e1nchez\u2010Garcia","sequence":"additional","affiliation":[{"name":"Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC) Universidad de C\u00f3rdoba, Hematology Department Hospital Universitario Reina Sof\u00eda  C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"L\u00f3pez\u00a0Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Universitario Ram\u00f3n y Cajal  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Garc\u00eda\u2010Cos\u00edo\u00a0Piqueras","sequence":"additional","affiliation":[{"name":"Anatomical Pathology Department Hospital Universitario Ram\u00f3n y Cajal, CIBERONC  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Castellvi","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Universitari Vall d'Hebron  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Julia","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Universitario Central de Asturias  Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Gonz\u00e1lez\u00a0de\u00a0Villambrosia","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Universitario Marqu\u00e9s de Valdecilla  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"G\u00f3mez\u00a0Codina","sequence":"additional","affiliation":[{"name":"Medical Oncology Department Hospital Universitari i Polit\u00e8cnic La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bel\u00e9n","family":"Navarro","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Universitario Puerta de Hierro  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Universitario Virgen del Roc\u00edo  Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Jos\u00e9","family":"Borrero","sequence":"additional","affiliation":[{"name":"Anatomical Pathology Department Hospital Universitario Virgen del Roc\u00edo, Instituto de Biomedicina de Sevilla (IBIS)\/Universidad de Sevilla  Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1ximo","family":"Fraga","sequence":"additional","affiliation":[{"name":"Pathology Department Hospital Cl\u00ednico Universitario Santiago  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Naves","sequence":"additional","affiliation":[{"name":"Medical Department Takeda Farmac\u00e9utica Espa\u00f1a S.A.  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