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Adelson Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005984","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005189","name":"Leukemia and Lymphoma Society","doi-asserted-by":"publisher","award":["SCOR\u201012206\u201017"],"award-info":[{"award-number":["SCOR\u201012206\u201017"]}],"id":[{"id":"10.13039\/100005189","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA016672"],"award-info":[{"award-number":["P30 CA016672"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Multiple myeloma (MM) primarily affects older patients. There are scarce data on the outcomes of young adults undergoing autologous transplantation (auto\u2010HCT). In this single\u2010centre analysis, we included 117 younger patients, with a median age of 37\u2009years (range 22\u201340) at transplant. Seventeen (15%) patients had high\u2010risk cytogenetics. Before transplant, 10% of patients achieved \u2265CR and 44% achieved \u2265VGPR. At best post\u2010transplant response, 56% and 77% of patients achieved \u2265CR and \u2265VGPR respectively. With a median follow\u2010up for survivors of 72.6\u2009months (range 0.9\u2013238.0), median PFS and OS were 43.1\u2009months (95% CI 31.2\u201365.0) and 146.6\u2009months (95% CI 100.0\u2013208.1) respectively. Patients who underwent auto\u2010HCT after 2010 had better median PFS (84.9\u2009months vs. 28.2\u2009months, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and OS (NR vs. 91.8\u2009months, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) compared with those transplanted earlier. In multi\u2010variate analysis, achieving \u2265CR as best post\u2010transplant response was associated with improved PFS (HR [95% CI] 0.55 [0.32\u20130.95], <jats:italic>p<\/jats:italic>\u2009=\u20090.032), while achieving \u2265VGPR was predictive of superior OS (0.32 [0.16\u20130.62], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Three patients (3%) developed a second primary malignancy. Younger MM patients had durable survival after auto\u2010HCT, which further improved after the availability of novel anti\u2010myeloma drugs in recent years. Depth of response following transplant remains a key predictor of survival.<\/jats:p>","DOI":"10.1111\/bjh.18944","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T06:29:56Z","timestamp":1687933796000},"page":"866-873","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Outcomes of young adults (aged\u2009\u2264\u200940\u2009years) with newly diagnosed multiple myeloma after up\u2010front autologous stem cell transplant"],"prefix":"10.1111","volume":"202","author":[{"given":"Oren","family":"Pasvolsky","sequence":"first","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center  Houston Texas USA"},{"name":"Institute of Hematology, Davidoff Cancer Center Rabin Medical Center  Petah\u2010Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv 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USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8545-3292","authenticated-orcid":false,"given":"Hans C.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Lymphoma and Myeloma The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krina K.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Lymphoma and Myeloma The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Partow","family":"Kebriaei","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priti","family":"Tewari","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Patient Care The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsay","family":"Crawford\u2010Suber","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery University of Texas Health Science Center at Houston, McGovern Medical School  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheeba K.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Lymphoma and Myeloma The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna M.","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Lymphoma and Myeloma The University of Texas MD Anderson Cancer Center  Houston Texas 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