{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:47:39Z","timestamp":1747183659716,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T00:00:00Z","timestamp":1687737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000174","name":"Division of Antarctic Infrastructure and Logistics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000174","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007109","name":"Universit\u00e0 degli Studi di Ferrara","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007109","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We explored the relevance of genomic microarrays (GM) in the refinement of prognosis in newly diagnosed low\u2010risk chronic lymphocytic leukaemia (CLL) patients as defined by isolated del(13q) or no lesions by a standard 4 probe fluorescence in situ hybridization (FISH) analysis. Compared to FISH, additional lesions were detected by GM in 27 of the 119 patients (22.7%). The concordance rate between FISH and GM was 87.4%. Discordant results between cytogenetic banding analysis (CBA) and GM were observed in 45\/119 cases (37.8%) and were mainly due to the intrinsic characteristics of each technique. The presence of additional lesions by GM was associated with age\u2009&gt;\u200965\u2009years (<jats:italic>p<\/jats:italic>\u2009=\u20090.047), advanced Binet stage (<jats:italic>p<\/jats:italic>\u2009=\u20090.001), CLL\u2010IPI score (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), a complex karyotype (<jats:italic>p<\/jats:italic>\u2009=\u20090.004) and a worse time\u2010to\u2010first treatment in multivariate analysis (<jats:italic>p<\/jats:italic>\u2009=\u20090.009). Additional lesions by GM were also significantly associated with a worse time\u2010to\u2010first treatment in the subset of patients with wild\u2010type <jats:italic>TP53<\/jats:italic> and mutated IGHV (<jats:italic>p<\/jats:italic>\u2009=\u20090.025). In CLL patients with low\u2010risk features, the presence of additional lesions identified by GM helps to identify a subset of patients with a worse outcome that could be proposed for a risk\u2010adapted follow\u2010up and for early treatment including targeted agents within clinical trials.<\/jats:p>","DOI":"10.1111\/bjh.18946","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T08:49:47Z","timestamp":1687769387000},"page":"953-959","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Additional lesions identified by genomic microarrays are associated with an inferior outcome in low\u2010risk chronic lymphocytic leukaemia patients"],"prefix":"10.1111","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8370-5190","authenticated-orcid":false,"given":"Gian Matteo","family":"Rigolin","sequence":"first","affiliation":[{"name":"Hematology Section St. Anna University Hospital  Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Traversa","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine Sapienza University  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviana","family":"Caputo","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine Sapienza University  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Del\u00a0Giudice","sequence":"additional","affiliation":[{"name":"Hematology, Department of Translational and Precision Medicine Sapienza University  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Bardi","sequence":"additional","affiliation":[{"name":"Hematology Section St. Anna University Hospital  Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Saccenti","sequence":"additional","affiliation":[{"name":"Hematology Section St. Anna University Hospital  Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9438-0355","authenticated-orcid":false,"given":"Sara","family":"Raponi","sequence":"additional","affiliation":[{"name":"Hematology, Department of Translational and Precision Medicine Sapienza University  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Ilari","sequence":"additional","affiliation":[{"name":"Hematology, Department of Translational and Precision Medicine Sapienza University  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana","family":"Cafforio","sequence":"additional","affiliation":[{"name":"Hematology, Department of Translational and Precision Medicine Sapienza University  Rome Italy"},{"name":"GenomeUp S.r.l.  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