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This is an IRB\u2010approved study of patients with histiocytic neoplasms whose BRAF and MEK inhibitors were interrupted after achieving complete or partial response by 18\u2010fluorodeoxyglucose positron emission tomography (FDG\u2010PET). 17\/22 (77%) of patients experienced disease relapse following treatment interruption. Achieving a complete response prior to interruption, having a mutation other than\n                    <jats:italic>BRAF<\/jats:italic>\n                    V600E, and receiving MEK inhibition only were each associated with a statistically significant improvement in relapse\u2010free survival. 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