{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T07:24:03Z","timestamp":1785223443229,"version":"3.55.0"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T00:00:00Z","timestamp":1689033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100161"],"award-info":[{"award-number":["82100161"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ22H080004"],"award-info":[{"award-number":["LQ22H080004"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>To reducing chemotherapy\u2010related toxicity, the chemo\u2010free regimens become a new trend of Ph\u2009+\u2009ALL treatment. Therefore, we conducted a phase 2 trial of dasatinib plus prednisone, as induction (Course I) and early consolidation (Courses II and III) treating newly diagnosed Ph\u2009+\u2009ALL. The trial was registered at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.chictr.org.cn\">www.chictr.org.cn<\/jats:ext-link>, ChiCTR2000038053. Forty\u2010one patients were enrolled from 15 hospitals. The complete remission (CR) was 95% (39\/41), including two elderly induction deaths. By the end of Course III, 25.6% (10\/39) of patients achieved a complete molecular response. With a median follow\u2010up of 15.4\u2009months, 2\u2010year disease\u2010free survival (DFS) were 100% and 33% for patients who receiving haematopoietic stem cell transplantation (HSCT) at CR1 and receiving chemotherapy alone respectively. When censored at time of HSCT, 2\u2010year DFS were 51% and 45% for young and elderly patients (<jats:italic>p<\/jats:italic>\u2009=\u20090.987). 2\u2010year overall survival were 45%, 86% and 100% for patients without HSCT, receiving HSCT after relapse and receiving HSCT at CR1 respectively. A total of 12 patients had marrow recurrences and one had CNS relapse, with 38% occurred early (between Courses I and III). IKZF1 gene deletion was shown to be associated with relapse (<jats:italic>p<\/jats:italic>\u2009=\u20090.019). This chemo\u2010free induction and early consolidation regimen was efficacious and well\u2010tolerated in de novo Ph\u2009+\u2009ALL. Allogeneic HSCT conferred definite survival advantage after chemo\u2010free induction.<\/jats:p>","DOI":"10.1111\/bjh.18975","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T06:24:50Z","timestamp":1689143090000},"page":"1119-1126","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Dasatinib plus prednisone as induction and consolidation for\u00a0adults with Ph\u2010positive acute lymphoblastic leukaemia: A\u00a0single\u2010arm, multicentre, phase 2 trial"],"prefix":"10.1111","volume":"202","author":[{"given":"Mixue","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital, Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Hematology Yinzhou Hospital Affiliated to Medical 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