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We performed genetic analyses, evaluated prognostic factors and the value of allogeneic haematopoietic stem cell transplantation (allo\u2010HSCT) in a homogenous adult AMKL patient cohort. We retrospectively analysed 38 adult patients with AMKL (median age: 58\u2009years, range: 21\u201380). Most received intensive treatment in AML Cooperative Group (AMLCG) trials between 2001 and 2016. Cytogenetic data showed an accumulation of adverse risk markers according to ELN 2017 and an unexpected high frequency of structural aberrations on chromosome arm 1q (33%). Most frequently, mutations occurred in <jats:italic>TET2<\/jats:italic> (23%), <jats:italic>TP53<\/jats:italic> (23%), <jats:italic>JAK2<\/jats:italic> (19%), <jats:italic>PTPN11<\/jats:italic> (19%) and <jats:italic>RUNX1<\/jats:italic> (15%). Complete remission rate in 33 patients receiving intensive chemotherapy was 33% and median overall survival (OS) was 33\u2009weeks (95% CI: 21\u201345). Patients undergoing allo\u2010HSCT (<jats:italic>n<\/jats:italic>\u2009=\u200914) had a superior median OS (68\u2009weeks; 95% CI: 11\u2013126) and relapse\u2010free survival (RFS) of 27\u2009weeks (95% CI: 4\u201350), although cumulative incidence of relapse after allo\u2010HSCT was high (62%). The prognosis of AMKL is determined by adverse genetic risk factors and therapy resistance. So far allo\u2010HSCT is the only potentially curative treatment option in this dismal AML subgroup.<\/jats:p>","DOI":"10.1111\/bjh.18982","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T04:00:07Z","timestamp":1689566407000},"page":"1165-1177","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Acute megakaryoblastic leukaemia shows high frequency of chromosome 1q aberrations and dismal outcome"],"prefix":"10.1111","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2220-2346","authenticated-orcid":false,"given":"Friederike","family":"Pastore","sequence":"first","affiliation":[{"name":"Department of Medicine III University Hospital, LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Gittinger","sequence":"additional","affiliation":[{"name":"Department of Medicine III University Hospital, LMU Munich  Munich 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