{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:47:46Z","timestamp":1747183666488,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,7,23]],"date-time":"2023-07-23T00:00:00Z","timestamp":1690070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006436","name":"Celgene","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006436","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Diffuse large B\u2010cell lymphoma (DLBCL) patients with relapsed or refractory (RR) disease have poor outcomes with current salvage regimens. We conducted a phase 2 trial to analyse the safety and efficacy of adding lenalidomide to R\u2010ESHAP (LR\u2010ESHAP) in patients with RR DLBCL. Subjects received 3\u2009cycles of lenalidomide 10\u2009mg\/day on days 1\u201314 of every 21\u2010day\u2009cycle, in combination with R\u2010ESHAP at standard doses. Responding patients underwent autologous stem\u2010cell transplantation (ASCT). The primary endpoint was the overall response rate (ORR) after 3\u2009cycles. Centralized cell\u2010of\u2010origin (COO) classification was performed. Forty\u2010six patients were included. The ORR after LR\u2010ESHAP was 67% (35% of patients achieved complete remission). Patients with primary refractory disease (<jats:italic>n<\/jats:italic>\u2009=\u200926) had significantly worse ORR than patients with non\u2010refractory disease (54% vs. 85%, <jats:italic>p<\/jats:italic>\u2009=\u20090.031). No differences in response rates according to the COO were observed. Twenty\u2010eight patients (61%) underwent ASCT. At a median follow\u2010up of 41\u2009months, the estimated 3\u2010year PFS and OS were 42% and 48%, respectively. The most common grade \u22653 adverse events were thrombocytopenia (70% of patients), neutropenia (67%) and anaemia (35%). There were no treatment\u2010related deaths during LR\u2010ESHAP cycles. In conclusion, LR\u2010ESHAP is a feasible salvage regimen with promising efficacy results for patients with RR DLBCL.<\/jats:p>","DOI":"10.1111\/bjh.18989","type":"journal-article","created":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T00:44:30Z","timestamp":1690159470000},"page":"202-211","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Lenalidomide in combination with <scp>R\u2010ESHAP<\/scp> in patients with relapsed or refractory diffuse large B\u2010cell lymphoma: A phase 2 study from <scp>GELTAMO<\/scp>"],"prefix":"10.1111","volume":"203","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6330-1028","authenticated-orcid":false,"given":"A.","family":"Mart\u00edn\u00a0Garc\u00eda\u2010Sancho","sequence":"first","affiliation":[{"name":"Hematology Department Hospital Universitario de Salamanca\u2010IBSAL, CIBERONC, Universidad de Salamanca  Salamanca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Baile","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Universitario de Salamanca\u2010IBSAL, CIBERONC, Universidad de Salamanca  Salamanca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Universitario Virgen del Roc\u00edo\/Virgen Macarena  Sevilla Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3066-4732","authenticated-orcid":false,"given":"I.","family":"Dlouhy","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Clinic  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7168-6538","authenticated-orcid":false,"given":"J. 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