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DAA therapy yielded undetectable HCV\u2010RNA, the complete response of cryoglobulinemia vasculitis and related signs, whilst the presence of B\u2010cell clones (evaluated by flow cytometry, IGHV, and BCL2\u2010IGH rearrangements), detected in 19\/23 cases at baseline, was maintained (17\/19). Similarly, IGHV intraclonal diversification, supporting an antigen\u2010driven selection mechanism, was identified in B\u2010cell clones at baseline and end of follow\u2010up. DAA therapy alone, despite HCV eradication and good immunological responses, was less effective on the pathological B\u2010cell clones.<\/jats:p>","DOI":"10.1111\/bjh.19002","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T03:15:53Z","timestamp":1690341353000},"page":"237-243","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Persistence of monoclonal B\u2010cell expansion and intraclonal diversification despite virus eradication in patients affected by hepatitis C virus\u2010associated lymphoproliferative disorders"],"prefix":"10.1111","volume":"203","author":[{"given":"Cesare","family":"Mazzaro","sequence":"first","affiliation":[{"name":"Clinical and Experimental Onco\u2010Haematology Unit Centro di Riferimento Oncologico di Aviano (CRO), IRCCS  Aviano 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