{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:24:38Z","timestamp":1789097078084,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T00:00:00Z","timestamp":1692057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018170","name":"Fondation Pierre Fabre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018170","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201011\u2010IDEX\u20100005\u201002"],"award-info":[{"award-number":["ANR\u201011\u2010IDEX\u20100005\u201002"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Sickle cell anaemia (SCA) is a monogenic disease with a highly variable clinical course. We aimed to investigate associations between microvascular function, haemolysis markers, blood viscosity and various types of SCA\u2010related organ damage in a multicentric sub\u2010Saharan African cohort of patients with SCA. In a cross\u2010sectional study, we selected seven groups of adult patients with SS phenotype in Dakar and Bamako based on the following complications: leg ulcer, priapism, osteonecrosis, retinopathy, high tricuspid regurgitant jet velocity (TRV), macro\u2010albuminuria or none. Clinical assessment, echocardiography, peripheral arterial tonometry, laboratory tests and blood viscosity measurement were performed. We explored statistical associations between the biological parameters and the six studied complications. Among 235 patients, 58 had high TRV, 46 osteonecrosis, 43 priapism, 33 leg ulcers, 31 retinopathy and 22 macroalbuminuria, whereas 36 had none of these complications. Multiple correspondence analysis revealed no cluster of complications. Lactate dehydrogenase levels were associated with high TRV, and blood viscosity was associated with retinopathy and the absence of macroalbuminuria. Despite extensive phenotyping of patients, no specific pattern of SCA\u2010related complications was identified. New biomarkers are needed to predict SCA clinical expression to adapt patient management, especially in Africa, where healthcare resources are scarce.<\/jats:p>","DOI":"10.1111\/bjh.19006","type":"journal-article","created":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T05:09:52Z","timestamp":1692421792000},"page":"319-326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Association of haemolysis markers, blood viscosity and microcirculation function with organ damage in sickle cell disease in <scp>sub\u2010Saharan<\/scp> Africa (the <scp>BIOCADRE<\/scp> study)"],"prefix":"10.1111","volume":"203","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8549-2275","authenticated-orcid":false,"given":"Brigitte","family":"Ranque","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Inserm, UMR S970, PARCC  Paris France"},{"name":"Service de M\u00e9decine Interne, H\u00f4pital Europ\u00e9en Georges Pompidou Assistance Publique des H\u00f4pitaux de Paris  Paris France"},{"name":"LABEX GREX Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mor","family":"Diaw","sequence":"additional","affiliation":[{"name":"Laboratoire de Physiologie et Explorations Fonctionnelles, Facult\u00e9 de M\u00e9decine Pharmacie et Odontologie Universit\u00e9 Cheikh Anta Diop de Dakar  Dakar Senegal"},{"name":"Unit\u00e9 Mixte Internationale (UMI 3189), \u201cEnvironnement, Sant\u00e9, Soci\u00e9t\u00e9s\u201d CNRS, UCAD, CNRST, USTTB, UGB  Dakar Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdoul Karim","family":"Dembele","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 des Antilles, Inserm, BIGR  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudine","family":"Lapoumeroulie","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 des Antilles, Inserm, BIGR  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucile","family":"Offredo","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Inserm, UMR S970, PARCC  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oumar","family":"Tessougue","sequence":"additional","affiliation":[{"name":"Centre de Recherche et de Lutte Contre la Dr\u00e9panocytose (CRLD)  Bamako Mali"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serigne Mourtalla","family":"Gueye","sequence":"additional","affiliation":[{"name":"Centre National de Transfusion Sanguine (CNTS)  Dakar Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dapa","family":"Diallo","sequence":"additional","affiliation":[{"name":"Centre de Recherche et de Lutte Contre la Dr\u00e9panocytose (CRLD)  Bamako Mali"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saliou","family":"Diop","sequence":"additional","affiliation":[{"name":"Centre National de Transfusion Sanguine (CNTS)  Dakar Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Colin\u2010Aronovicz","sequence":"additional","affiliation":[{"name":"LABEX GREX Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 des Antilles, Inserm, BIGR  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Jouven","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Inserm, UMR S970, PARCC  Paris France"},{"name":"LABEX GREX Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Blanc\u2010Brude","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Inserm, UMR S970, PARCC  Paris France"},{"name":"LABEX GREX Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010Louis","family":"Tharaux","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Inserm, UMR S970, PARCC  Paris France"},{"name":"LABEX GREX Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Le\u00a0Jeune","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Inserm, UMR S970, PARCC  Paris France"},{"name":"Service de M\u00e9decine Interne, H\u00f4pital Avicenne, Bobigny Assistance\u2010Publique H\u00f4pitaux de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9232-0268","authenticated-orcid":false,"given":"Philippe","family":"Connes","sequence":"additional","affiliation":[{"name":"LABEX GREX Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Universit\u00e9 Lyon 1, Laboratoire LIBM EA7424, Equipe \u00abBiologie Vasculaire et du Globule Rouge\u00bb, COMUE  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8715-9836","authenticated-orcid":false,"given":"Marc","family":"Romana","sequence":"additional","affiliation":[{"name":"LABEX GREX Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 des Antilles, Inserm, BIGR  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3251-1310","authenticated-orcid":false,"given":"Caroline","family":"Le\u00a0Van\u00a0Kim","sequence":"additional","affiliation":[{"name":"LABEX GREX Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 des Antilles, Inserm, BIGR  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/178792a0"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/10739680802279394"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.229989"},{"key":"e_1_2_11_5_1","first-page":"1785","article-title":"Vasculopathy in sickle cell disease: from red blood cell sickling to vascular dysfunction","volume":"11","author":"Nader E","year":"2011","journal-title":"Compr Physiol"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2006.07.001"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61229-X"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2011.09.013"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(22)00004-7"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000280"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198504043121403"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804799105"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-06-432849"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535370216636726"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.021015"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(14)00007-6"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-13-83"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-12-755777"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1005565"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-06-2373"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21162"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0278478"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.6.1584"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000044943.12533.A8"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.112.191874"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq010"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/08880010903271689"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2010.02444.x"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17242"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-01-480277"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.70.7.522"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3233\/CH-2012-1622"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.3233\/CH-131772"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020007645"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2022.2041410"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21838"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.19006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T19:22:07Z","timestamp":1696447327000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.19006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,15]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1111\/bjh.19006"],"URL":"https:\/\/doi.org\/10.1111\/bjh.19006","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,15]]},"assertion":[{"value":"2023-04-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}