{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:47:49Z","timestamp":1747183669046,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T00:00:00Z","timestamp":1690761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000950","name":"Cancer Council South Australia","doi-asserted-by":"publisher","award":["022213"],"award-info":[{"award-number":["022213"]}],"id":[{"id":"10.13039\/501100000950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1146253","1160833"],"award-info":[{"award-number":["1146253","1160833"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Donor\u2010derived haematological neoplasms, in which recipients present with haematological malignancies that have evolved from transplant donor stem cells, have previously been described for myelodysplastic syndrome, myeloproliferative neoplasms, acute myeloid leukaemia and less often, leukaemias of lymphoid origin. Here we describe a rare and complex case of donor\u2010derived T\u2010cell acute lymphoblastic leukaemia with a relatively short disease latency of less than 4\u2009years. Through genomic and in vitro analyses, we identified novel mutations in <jats:italic>NOTCH1<\/jats:italic> as well as a novel activating mutation in <jats:italic>STAT5B<\/jats:italic>; the latter targetable with the clinically available drugs, venetoclax and ruxolitinib.<\/jats:p>","DOI":"10.1111\/bjh.19008","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T07:46:16Z","timestamp":1690789576000},"page":"282-287","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Case report: Rare case of donor cell\u2010derived T\u2010cell acute lymphoblastic leukaemia in a female patient after receiving an allo\u2010transplant from her male sibling"],"prefix":"10.1111","volume":"203","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1912-7602","authenticated-orcid":false,"given":"Laura N.","family":"Eadie","sequence":"first","affiliation":[{"name":"Precision Cancer Medicine Theme South Australian Health and Medical Research Institute  Adelaide South Australia Australia"},{"name":"Faculty of Health and Medical Sciences University of Adelaide  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5043-6943","authenticated-orcid":false,"given":"Jacqueline A.","family":"Rehn","sequence":"additional","affiliation":[{"name":"Precision Cancer Medicine Theme South Australian Health and Medical Research Institute  Adelaide South Australia Australia"},{"name":"Faculty of Health and Medical Sciences University of Adelaide  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caitlin E.","family":"Schutz","sequence":"additional","affiliation":[{"name":"Precision Cancer Medicine Theme South Australian Health and Medical Research Institute  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7497-6477","authenticated-orcid":false,"given":"Susan L.","family":"Heatley","sequence":"additional","affiliation":[{"name":"Precision Cancer Medicine Theme South Australian Health and Medical Research Institute  Adelaide South Australia Australia"},{"name":"Faculty of Health and Medical Sciences University of Adelaide  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika M.","family":"Kutyna","sequence":"additional","affiliation":[{"name":"Precision Cancer Medicine Theme South Australian Health and Medical Research Institute  Adelaide South Australia Australia"},{"name":"Faculty of Health and Medical Sciences University of Adelaide  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devendra K.","family":"Hiwase","sequence":"additional","affiliation":[{"name":"Precision Cancer Medicine Theme South Australian Health and Medical Research Institute  Adelaide South Australia Australia"},{"name":"Faculty of Health and Medical Sciences University of Adelaide  Adelaide South Australia Australia"},{"name":"Department of Haematology Royal Adelaide Hospital  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4844-333X","authenticated-orcid":false,"given":"Deborah L.","family":"White","sequence":"additional","affiliation":[{"name":"Precision Cancer Medicine Theme South Australian Health and Medical Research Institute  Adelaide South Australia Australia"},{"name":"Faculty of Health and Medical Sciences University of Adelaide  Adelaide South Australia Australia"},{"name":"Australasian Leukaemia &amp; Lymphoma Group (ALLG)  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7558-9927","authenticated-orcid":false,"given":"David T.","family":"Yeung","sequence":"additional","affiliation":[{"name":"Precision Cancer Medicine Theme South Australian Health and Medical Research Institute  Adelaide South Australia Australia"},{"name":"Faculty of Health and Medical Sciences University of Adelaide  Adelaide South Australia Australia"},{"name":"Department of Haematology Royal Adelaide Hospital  Adelaide South Australia Australia"},{"name":"Australasian Leukaemia &amp; Lymphoma Group (ALLG)  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,31]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12484"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-04-777029"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019001807"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019001793"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408617"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-04-641100"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003168"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1010300"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27472-5"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.BCD-19-0041"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-016-3195-z"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3909"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)70065-9"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.116"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0218-6"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPPJUQ9DNR1GHP"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-018-0015-6"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.19008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T19:21:52Z","timestamp":1696447312000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.19008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,31]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1111\/bjh.19008"],"URL":"https:\/\/doi.org\/10.1111\/bjh.19008","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"type":"print","value":"0007-1048"},{"type":"electronic","value":"1365-2141"}],"subject":[],"published":{"date-parts":[[2023,7,31]]},"assertion":[{"value":"2023-05-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}