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The question of a possible oligogenic model of inheritance influencing phenotypic heterogeneity is raised, with discussion of the benefits and challenges of sequencing technology used to enhance discovery in this space. Considerable work lies ahead in order to achieve diagnostic and prognostic precision and subsequently provide targeted management to this complex cohort of patients.<\/jats:p>","DOI":"10.1111\/bjh.19039","type":"journal-article","created":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T05:10:52Z","timestamp":1692421852000},"page":"355-368","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Congenital fibrinogen disorders: Strengthening <scp>genotype\u2013phenotype<\/scp> correlations through novel genetic diagnostic tools"],"prefix":"10.1111","volume":"203","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5539-0673","authenticated-orcid":false,"given":"Radha","family":"Ramanan","sequence":"first","affiliation":[{"name":"Department of Haematology Alfred Hospital  Melbourne Victoria Australia"},{"name":"Australian Centre for Blood Diseases Monash University  Melbourne Victoria Australia"},{"name":"Department of Pathology Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9832-6871","authenticated-orcid":false,"given":"James D.","family":"McFadyen","sequence":"additional","affiliation":[{"name":"Department of Haematology Alfred Hospital  Melbourne Victoria Australia"},{"name":"Australian Centre for Blood Diseases Monash University  Melbourne Victoria Australia"},{"name":"Atherothrombosis and Vascular Biology Program Baker Heart and Diabetes Institute  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3644-7093","authenticated-orcid":false,"given":"Andrew C.","family":"Perkins","sequence":"additional","affiliation":[{"name":"Department of Haematology Alfred Hospital  Melbourne Victoria Australia"},{"name":"Australian Centre for Blood Diseases Monash University  Melbourne Victoria Australia"},{"name":"Department of Pathology Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1989-959X","authenticated-orcid":false,"given":"Huyen A.","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Haematology Alfred Hospital  Melbourne Victoria Australia"},{"name":"Australian Centre for Blood Diseases Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,15]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-02-0595"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18122711"},{"key":"e_1_2_17_4_1","unstructured":"Australian Bleeding Disorders Registry (ABDR) | National Blood Authority [Internet]. 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