{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:14:22Z","timestamp":1757704462639,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:00:00Z","timestamp":1692748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The thrombopoietin receptor agonists (TPO\u2010RA) were recommended for primary immune thrombocytopenia (ITP) during the pandemic of COVID\u201019. However, the incidence of thrombocytosis and thrombosis was sporadically reported in the chronic immune thrombocytopenia (CITP) patients receiving TPO\u2010RA during the COVID\u201019 infection. With the local prevalence of COVID\u201019 in December 2022 in the Beijing area, we got more powerful evidence about the change in platelet (Plt) counts associated with COVID\u201019 infection. A single\u2010centre observational cohort study was performed from the beginning of December 2022 to the end of February 2023 to enrol CITP children treated with TPO\u2010RA alone as the second\u2010line treatment and suffering from the COVID\u201019 infection in December 2022. The Plt counts before, during and after COVID\u201019 infection were collected. In total, 67 (34 males and 33 females) patients with 8.10 (2.15, 15.70) years of age were enrolled. Sixty\u2010three patients who had responded to the TPO\u2010RA showed a transient increase in Plt counts after the infection of COVID\u201019. The time of starting to increase was on Day 3 (2, 7), and to the peak level on Day 14 (7, 19) of infection with the peak Plt count was 289 (88, 1974)\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L. With at least 2\u2009months observation period from COVID\u201019 infection, the Plt counts of 100% (63\/63) patients declined to the baseline on Day 25 (14, 41). The phenomenon of transient increase in Plt counts has been shown in the CITP children who responded to TPO\u2010RA when suffering from COVID\u201019 infection.<\/jats:p>","DOI":"10.1111\/bjh.19040","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T08:30:27Z","timestamp":1692779427000},"page":"384-388","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Transient increase in platelet counts associated with <scp>COVID<\/scp>\u201019 infection during <scp>TPO\u2010RA<\/scp> as the second\u2010line treatment in children with <scp>ITP<\/scp>"],"prefix":"10.1111","volume":"203","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7363-5101","authenticated-orcid":false,"given":"Zhifa","family":"Wang","sequence":"first","affiliation":[{"name":"Hemophilia Comprehensive Care Center, Hematology Center, Beijing Key Laboratory of Pediatric Hematology\u2010Oncology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Diseases in Children, Ministry of Education Beijing Children's Hospital, Capital Medical University, National Center for Children's Health  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0048-2658","authenticated-orcid":false,"given":"Xiaoling","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Beijing Children's Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Beijing Children's Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinxi","family":"Meng","sequence":"additional","affiliation":[{"name":"Hemophilia Comprehensive Care Center, Hematology Center, Beijing Key Laboratory of Pediatric Hematology\u2010Oncology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Diseases in Children, Ministry of Education Beijing Children's Hospital, Capital Medical University, National Center for Children's Health  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyao","family":"Ma","sequence":"additional","affiliation":[{"name":"Hemophilia Comprehensive Care Center, Hematology Center, Beijing Key Laboratory of Pediatric Hematology\u2010Oncology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Diseases in Children, Ministry of Education Beijing Children's Hospital, Capital Medical University, National Center for Children's Health  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenping","family":"Chen","sequence":"additional","affiliation":[{"name":"Hematologic Disease Laboratory, Hematology Center, Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Diseases in Children, Ministry of Education Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4030-209X","authenticated-orcid":false,"given":"Runhui","family":"Wu","sequence":"additional","affiliation":[{"name":"Hemophilia Comprehensive Care Center, Hematology Center, Beijing Key Laboratory of Pediatric Hematology\u2010Oncology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Diseases in Children, Ministry of Education Beijing Children's Hospital, Capital Medical University, National Center for Children's Health  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,23]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2020-001439"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2021.06.006"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-217871"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000001109"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17077"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02212-y"},{"key":"e_1_2_13_8_1","unstructured":"China CDC report [cited 2023 Feb 25]. 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