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We present the outcome of 33 patients with AL who failed on daratumumab (due to haematological relapse in 21 [64%] patients and inadequate haematological response in 12 [36%]) and received further treatment. Overall response rate in the post\u2010daratumumab failure treatment was 55% (CR\/VGPR: 14 [42%] and PR: 3 [9%] patients). Patients retreated with daratumumab and patients harbouring +1q21 had lower rates of response. Treatment of patients with AL who fail daratumumab therapy is feasible when non\u2010cross\u2010resistant drugs or other targeted therapies are available.<\/jats:p>","DOI":"10.1111\/bjh.19042","type":"journal-article","created":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T05:22:32Z","timestamp":1692076952000},"page":"411-415","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Outcomes of patients with light chain (<scp>AL<\/scp>) amyloidosis after failure of daratumumab\u2010based therapy"],"prefix":"10.1111","volume":"203","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6926-0351","authenticated-orcid":false,"given":"Foteini","family":"Theodorakakou","sequence":"first","affiliation":[{"name":"Department of Clinical Therapeutics National and Kapodistrian University of Athens, School of Medicine  Athens 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