{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T22:17:24Z","timestamp":1755037044254,"version":"3.40.5"},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:00:00Z","timestamp":1692230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>Recent clinical studies demonstrated the achievement of lymphoma responses in patients with Hepatitis C virus\u2010associated indolent lymphoproliferative disorders (LPD) receiving direct\u2010acting antivirals (DAAs) as their sole treatment. However, the molecular mechanisms underlying LPD responses to DAAs are still poorly understood. In their paper the authors provide new molecular insights on this issue, reporting intraclonal diversification and persistence of B\u2010cell clones in most cases, despite viral eradication and beneficial clinical outcome. These provocative data suggest that the achievement of molecular response is probably not required for a \u2018functional cure\u2019 of these patients. Further comprehensive immunogenetic and mutational studies would be fundamental to dissect this biological puzzle and, ultimately, to refine improved treatment strategies in this setting.<\/jats:p><jats:p>Commentary on: Mazzaro et al. Persistence of monoclonal B\u2010cell expansion and intraclonal diversification despite virus eradication in patients affected by hepatitis C virus\u2010associated lymphoproliferative disorders. Br J Haematol 2023;203:237\u2010243.<\/jats:p>","DOI":"10.1111\/bjh.19043","type":"journal-article","created":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T04:40:02Z","timestamp":1692333602000},"page":"154-157","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Deciphering molecular complexity of <scp>HCV<\/scp>\u2010associated lymphoproliferation"],"prefix":"10.1111","volume":"203","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0905-5927","authenticated-orcid":false,"given":"Michele","family":"Merli","sequence":"first","affiliation":[{"name":"Division of Hematology University Hospital \u201cOspedale di Circolo e Fondazione Macchi \u2010 ASST Sette Laghi\u201d  Varese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8068-5289","authenticated-orcid":false,"given":"Francesco","family":"Passamonti","sequence":"additional","affiliation":[{"name":"Division of Hematology Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"},{"name":"Universit\u00e0 degli Studi di Milano  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9504-991X","authenticated-orcid":false,"given":"Luca","family":"Arcaini","sequence":"additional","affiliation":[{"name":"Division of Hematology Fondazione IRCCS Policlinico San Matteo  Pavia Italy"},{"name":"Department of Molecular Medicine University of Pavia  Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,17]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238\u2010020\u201000615\u20106"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu166"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010019\u20100687\u20102"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.00668"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.19002"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2022000362"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v99.7.2541"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx635"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41435\u2010020\u20100093\u20109"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26167"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010023\u201001868\u20102"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.19043","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T19:21:12Z","timestamp":1696447272000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.19043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,17]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1111\/bjh.19043"],"URL":"https:\/\/doi.org\/10.1111\/bjh.19043","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"type":"print","value":"0007-1048"},{"type":"electronic","value":"1365-2141"}],"subject":[],"published":{"date-parts":[[2023,8,17]]},"assertion":[{"value":"2023-08-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}