{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T04:15:06Z","timestamp":1788322506742,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T00:00:00Z","timestamp":1694304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    This study retrospectively evaluated the outcome of salvage therapy in 51 patients who failed axicabtagene ciloleucel or tisagenlecleucel for relapsed\/refractory large B\u2010cell lymphomas. Of these patients, 22 (43%) were enrolled in clinical trials (glofitamab or loncastuximab tesirine\u2009+\u2009ibrutinib), whereas 29 received standard therapies (lenalidomide [Len], checkpoint inhibitors [CPIs], ibrutinib [I], chemoimmunotherapy and radiotherapy) or supportive care. Overall, 26 of 39 (67%) treated patients received a treatment based on immunotherapy (glofitamab, CPI, Len) that was mainly represented by bispecific antibody (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200918). In this subgroup, plasma samples were collected and analysed for circulating tumour DNA (ctDNA) using cancer\u2010personalized profiling by deep sequencing (CAPP\u2010seq). The study found that patients with high ctDNA had poor outcomes. At a median follow\u2010up of 11.7\u2009months, the estimated 12\u2010month overall survival (OS) was 35%. Factors adversely affecting the prognosis in the multivariable model were the absence of response to CAR T\u2010cell therapy (HR: 3.08;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0109) and a diagnosis other than PMBCL and t\u2010FL (HR: 4.54;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0069). The outcome of patients failing CAR T cells is poor and requires further investigation.\n                  <\/jats:p>","DOI":"10.1111\/bjh.19057","type":"journal-article","created":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T21:29:50Z","timestamp":1694381390000},"page":"151-159","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Outcome after chimeric antigen receptor (\n                    <scp>CAR<\/scp>\n                    ) T\u2010cell therapy failure in large B\u2010cell lymphomas"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0332-5412","authenticated-orcid":false,"given":"Anna","family":"Dodero","sequence":"first","affiliation":[{"name":"Department of Hematology Fondazione IRCCS Istituto Nazionale dei Tumori  Milan 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University  Rozzano\u2010Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina Maria","family":"Nierychlewska","sequence":"additional","affiliation":[{"name":"Department of Hematology Istituto Europeo di Oncologia  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Di Rocco","sequence":"additional","affiliation":[{"name":"Department of Hematology University la Sapienza  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Lorenzini","sequence":"additional","affiliation":[{"name":"Department of Pathology Fondazione IRCCS Istituto Nazionale dei Tumori  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoud","family":"Rahal","sequence":"additional","affiliation":[{"name":"Department of Pathology IRCCS Humanitas Research Hospital  Rozzano\u2010Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"De 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