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A role for an abnormal T\u2010cell compartment has been established in ITP pathogenesis and treatments that increase platelet counts in patients with ITP have shown improvements in T\u2010cell profiles. On the other hand, patients who were refractory to treatment appear to retain the T\u2010cell abnormalities as before. Myeloid\u2010derived suppressive cells (MDSCs) are also emerging as key contributors to the immune pathology of ITP and response to treatment. In this review, we will discuss how various treatments affect the T\u2010cell and MDSC compartments in ITP. The review will focus on studies that have examined the underlying mechanisms and\/or genetic basis responsible for refractoriness to a given treatment and highlight remaining challenges in identifying factors and mechanisms to predict response to treatment.<\/jats:p>","DOI":"10.1111\/bjh.19079","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T03:20:29Z","timestamp":1695352829000},"page":"54-61","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["The role of T cells and myeloid\u2010derived suppressor cells in refractory immune thrombocytopenia"],"prefix":"10.1111","volume":"203","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1968-0101","authenticated-orcid":false,"given":"Karina","family":"Yazdanbakhsh","sequence":"first","affiliation":[{"name":"Laboratory of Complement Biology Lindsley F. 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