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Currently, sustained remission off treatment (SROT) is a clinical definition describing patients who can discontinue their ITP treatment without risk and maintain a state of remission. Different treatment strategies are presently being evaluated with the goal of attaining SROT, mostly combining drugs targeting the innate and\/or the adaptive immune system, the inflammation state, so as increasing the platelet load. In this sense, thrombopoietin receptor agonists (TPO\u2010RAs) have shown promising results if used as upfront treatment. TPO\u2010RAs seem to exhibit immunomodulation and immune tolerance properties, increasing not only the platelet antigen mass but also increasing the transforming growth factor\u2010\u03b2 concentration, and stimulating regulatory T and B lymphocytes. However, more immunological studies are needed to establish accurate molecular alterations in ITP that are potentially reversed with treatments.<\/jats:p>","DOI":"10.1111\/bjh.19082","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T23:20:29Z","timestamp":1695338429000},"page":"101-111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Early immunomodulation in immune thrombocytopenia\u2014A report of the\n                    <scp>ICIS<\/scp>\n                    meeting in Lenzerheide, Switzerland 2022"],"prefix":"10.1111","volume":"203","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9575-1816","authenticated-orcid":false,"given":"Tom\u00e1s Jos\u00e9","family":"Gonz\u00e1lez\u2010L\u00f3pez","sequence":"first","affiliation":[{"name":"Department of Haematology Hospital Universitario de Burgos  Burgos 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