{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:19:17Z","timestamp":1784297957805,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T00:00:00Z","timestamp":1693612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Data from 200 children with high\u2010risk acute myeloid leukaemia who underwent their first haploidentical haematopoietic stem cell transplantation (haplo\u2010HSCT) between 2015 and 2021 at our institution were analysed. The 4\u2010year overall survival (OS), event\u2010free survival (EFS) and cumulative incidence of relapse (CIR) were 71.9%, 62.3% and 32.4% respectively. The 100\u2010day cumulative incidences of grade II\u2013IV and III\u2013IV acute graft\u2010versus\u2010host disease (aGVHD) were 41.1% and 9.5% respectively. The 4\u2010year cumulative incidence of chronic GVHD (cGVHD) was 56.1%, and that of moderate\u2010to\u2010severe cGVHD was 27.3%. Minimal residual disease (MRD)\u2010positive (MRD+) status pre\u2010HSCT was significantly associated with lower survival and a higher risk of relapse. The 4\u2010year OS, EFS and CIR differed significantly between patients with MRD+ pre\u2010HSCT (<jats:italic>n<\/jats:italic>\u2009=\u200997; 63.4%, 51.4% and 41.0% respectively) and those with MRD\u2010negative (MRD\u2010) pre\u2010HSCT (<jats:italic>n<\/jats:italic>\u2009=\u2009103; 80.5%, 73.3% and 23.8% respectively). Multivariate analysis also revealed that acute megakaryoblastic leukaemia without Down syndrome (non\u2010DS\u2010AMKL) was associated with extremely poor outcomes (hazard ratios and 95% CIs for OS, EFS and CIR: 3.110 (1.430\u20136.763), 3.145 (1.628\u20136.074) and 3.250 (1.529\u20136.910) respectively; <jats:italic>p<\/jats:italic>\u2010values were 0.004, 0.001 and 0.002 respectively). Thus, haplo\u2010HSCT can be a therapy option for these patients, and MRD status pre\u2010HSCT significantly affects the outcomes. As patients with non\u2010DS\u2010AMKL have extremely poor outcomes, even with haplo\u2010HSCT, a combination of novel therapies is urgently needed.<\/jats:p>","DOI":"10.1111\/bjh.19086","type":"journal-article","created":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T08:39:47Z","timestamp":1693643987000},"page":"585-594","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Long\u2010term follow\u2010up of haploidentical haematopoietic stem cell transplantation in paediatric patients with high\u2010risk acute myeloid leukaemia: Report from a single centre"],"prefix":"10.1111","volume":"204","author":[{"given":"Lu","family":"Bai","sequence":"first","affiliation":[{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, Research Unit of Key Technique for Diagnosis and Treatment of Hematologic Malignancies, Peking\u2010Tsinghua Center for Life Science, Chinese Academic of Medical Sciences, Peking University Institute of Hematology Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0051-2095","authenticated-orcid":false,"given":"Zhi\u2010Xiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Peking University People's Hospital, Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guan\u2010Hua","family":"Hu","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, Research Unit of Key Technique for Diagnosis and Treatment of Hematologic Malignancies, Peking\u2010Tsinghua Center for Life Science, Chinese Academic of Medical Sciences, Peking University Institute of Hematology Peking University People's Hospital  Beijing 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Diagnosis and Treatment of Hematologic Malignancies, Peking\u2010Tsinghua Center for Life Science, Chinese Academic of Medical Sciences, Peking University Institute of Hematology Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1253-7465","authenticated-orcid":false,"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, Research Unit of Key Technique for Diagnosis and Treatment of Hematologic Malignancies, Peking\u2010Tsinghua Center for Life Science, Chinese Academic of Medical Sciences, Peking University Institute of Hematology Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen\u2010Hua","family":"Yan","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory 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