{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T22:45:55Z","timestamp":1752101155115,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T00:00:00Z","timestamp":1693872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We analysed COVID\u201019 infection outcomes of 129\/241 chronic lymphocytic leukaemia (CLL) (53.9%) and 22\/55 monoclonal B\u2010lymphocytosis (MBL) (40.0%) patients following multiple vaccine doses aiming for maximum measured anti\u2010spike antibody response. Throughout the pandemic to date, there were 8\/129 CLL (6.2%) patients hospitalised, with one death (0.8%). No MBL patients were hospitalised or died. CLL patients with COVID\u201019 had lower anti\u2010spike levels (3778.8\u2009AU\/mL) than those without (13\u2009486.8\u2009AU\/mL; <jats:italic>p<\/jats:italic>\u2009=\u20090.0061). Anti\u2010nucleocapsid antibody was detected in 29.8% within 2\u2009months and 17.5% &gt;6\u2009months. Of COVID\u201019\u2010infected CLL patients, 47.3% received anti\u2010viral therapy. A multiple vaccine dosing strategy to achieve measured maximum antibody is highly effective in preventing severe COVID\u201019.<\/jats:p>","DOI":"10.1111\/bjh.19087","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T02:57:11Z","timestamp":1693969031000},"page":"487-491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Repeated <scp>COVID\u201019<\/scp> vaccination to maximum antibody response yields very low mortality and hospitalisation rates in patients with <scp>CLL<\/scp> and <scp>MBL<\/scp>"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1344-5143","authenticated-orcid":false,"given":"Yandong","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Haematology Royal North Shore Hospital  St Leonards New South Wales Australia"},{"name":"Kolling Institute Royal North Shore Hospital, University of Sydney  St Leonards New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6337-1496","authenticated-orcid":false,"given":"Jane A.","family":"Freeman","sequence":"additional","affiliation":[{"name":"Department of Haematology and Flow Cytometry Healius Laverty Pathology  Macquarie Park New South Wales Australia"},{"name":"Northern Haematology and Oncology Group Sydney Adventist Hospital  Wahroonga New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7445-4660","authenticated-orcid":false,"given":"Ian","family":"Kerridge","sequence":"additional","affiliation":[{"name":"Department of Haematology Royal North Shore Hospital  St Leonards New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Downe","sequence":"additional","affiliation":[{"name":"Department of Haematology and Flow Cytometry Healius Laverty Pathology  Macquarie Park New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kartik","family":"Naidu","sequence":"additional","affiliation":[{"name":"Department of Microbiology Healius Laverty Pathology  Macquarie Park New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliette","family":"Holland","sequence":"additional","affiliation":[{"name":"Department of Microbiology Healius Laverty Pathology  Macquarie Park New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1928-2098","authenticated-orcid":false,"given":"Stephen P.","family":"Mulligan","sequence":"additional","affiliation":[{"name":"Department of Haematology Royal North Shore Hospital  St Leonards New South Wales Australia"},{"name":"Kolling Institute Royal North Shore Hospital, University of Sydney  St Leonards New South Wales Australia"},{"name":"Department of Haematology and Flow Cytometry Healius Laverty Pathology  Macquarie Park New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.706285"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-020-0959-x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020006965"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022016147"},{"volume-title":"NSW respiratory surveillance reports\u2014COVID\u201019 and influenza","year":"2023","key":"e_1_2_11_6_1"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.104270"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05053-w"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022017814"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18014"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-09-806398"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.15247"},{"key":"e_1_2_11_13_1","unstructured":"COVID19\u2010Blood\u2010Donor\u2010Report\u2010Round4\u2010Nov\u2010Dec\u20102022. 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