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This study aimed to identify molecular biomarkers for AITL based on peripheral cell\u2010free DNA (cfDNA) that could be used to predict prognosis and guide treatment non\u2010invasively. A customized panel containing 46 genes was used to study pretreatment cfDNA and paired tumour tissues in 64 Chinese AITL patients from three clinical centres, and gene mutations in cfDNA and tumour tissue were assessed for concordance (34 paired samples). Then, the association of gene mutations and prognosis was analysed, and a functional enrichment analysis was performed. The sequencing results showed good consistency between cfDNA samples and paired tissue samples. <jats:italic>KDM5A<\/jats:italic>, <jats:italic>STAT1<\/jats:italic>, <jats:italic>FANCM<\/jats:italic>, <jats:italic>ERBB4<\/jats:italic>, <jats:italic>PIK3R5<\/jats:italic> and <jats:italic>NSD1<\/jats:italic> were identified as novel recurrent mutations. Mutations in <jats:italic>FANCM<\/jats:italic> or combinations of <jats:italic>RHOA<\/jats:italic>, <jats:italic>KDM5A<\/jats:italic> and <jats:italic>FAT1<\/jats:italic> were associated with poor prognosis. Additionally, functional analysis revealed that <jats:italic>RHOA<\/jats:italic><jats:sup>G17<\/jats:sup> might serve as a predictive biomarker of PD\u20101 blockade respondence. Our findings confirmed the role of cfDNA as a liquid biopsy in AITL, and revealed novel molecular determinants that can stratify patients and guide treatment options.<\/jats:p>","DOI":"10.1111\/bjh.19089","type":"journal-article","created":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T10:18:53Z","timestamp":1693390733000},"page":"807-819","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Angioimmunoblastic T\u2010cell lymphoma: Novel recurrent mutations and prognostic biomarkers by cell\u2010free <scp>DNA<\/scp> profiling"],"prefix":"10.1111","volume":"203","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4226-7451","authenticated-orcid":false,"given":"Chunlan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Hematology West China Hospital, Sichuan University  Chengdu 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