{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T03:17:29Z","timestamp":1784258249136,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T00:00:00Z","timestamp":1694304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Azacitidine (Aza) is a mainstay of treatment for patients with acute myeloid leukaemia (AML) ineligible for induction chemotherapy and other high\u2010risk myelodysplastic syndromes (MDS). Only half of patients respond, and almost all will eventually relapse. There are no predictive markers of response to Aza. Aza is detoxified in the liver by cytidine deaminase (CDA). Here, we investigated the association between CDA phenotype, toxicity and efficacy of Aza in real\u2010world adult patients. Median overall survival (OS) was 15\u2009months and 13\u2009months in AML and high\u2010risk MDS patients respectively. In addition, our data suggest that delaying Aza treatment was not associated with lack of efficacy and should not be considered a signal to switch to an alternative treatment. Half of the patients had deficient CDA activity (i.e. &lt;2\u2009UA\/mg), with a lower proportion of deficient patients in MDS patients (34%) compared to AML patients (67%). In MDS patients, CDA deficiency correlated with longer landmark OS (14 vs. 8\u2009months; <jats:italic>p<\/jats:italic>\u2009=\u20090.03), but not in AML patients. Taken together, our data suggest that CDA is an independent covariate and may therefore be a marker for predicting clinical outcome in MDS patients treated with Aza.<\/jats:p>","DOI":"10.1111\/bjh.19096","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T05:59:20Z","timestamp":1694411960000},"page":"625-636","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cytidine deaminase status as a marker of response to azacytidine treatment in <scp>MDS<\/scp> and <scp>AML<\/scp> patients"],"prefix":"10.1111","volume":"203","author":[{"given":"Melanie","family":"Donnette","sequence":"first","affiliation":[{"name":"SMARTc: Simulation and Modeling: Adaptative Response for Therapeutics in Cancer, Facult\u00e9 de Pharmacie de Marseille, CRCM Inserm UMR 1068  Marseille France"},{"name":"Facult\u00e9 de Pharmacie de Marseille, COMPO, CRCM Inserm UMR 1068, INRIA Sophia Antipolis  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mourad","family":"Hamimed","sequence":"additional","affiliation":[{"name":"SMARTc: Simulation and Modeling: Adaptative Response for Therapeutics in Cancer, Facult\u00e9 de Pharmacie de Marseille, CRCM Inserm UMR 1068  Marseille France"},{"name":"Facult\u00e9 de Pharmacie de Marseille, COMPO, CRCM Inserm UMR 1068, INRIA Sophia Antipolis  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Ciccolini","sequence":"additional","affiliation":[{"name":"SMARTc: Simulation and Modeling: Adaptative Response for Therapeutics in Cancer, Facult\u00e9 de Pharmacie de Marseille, CRCM Inserm UMR 1068  Marseille France"},{"name":"Facult\u00e9 de Pharmacie de Marseille, COMPO, CRCM Inserm UMR 1068, INRIA Sophia Antipolis  Marseille France"},{"name":"Laboratoire de Pharmacocin\u00e9tique et Toxicologie La Timone University Hospital of Marseille  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Sicard","sequence":"additional","affiliation":[{"name":"SMARTc: Simulation and Modeling: Adaptative Response for Therapeutics in Cancer, Facult\u00e9 de Pharmacie de Marseille, CRCM Inserm UMR 1068  Marseille France"},{"name":"Facult\u00e9 de Pharmacie de Marseille, COMPO, CRCM Inserm UMR 1068, INRIA Sophia Antipolis  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Correard","sequence":"additional","affiliation":[{"name":"Pharmacie La Timone University Hospital of Marseille  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Farnault","sequence":"additional","affiliation":[{"name":"Hematology and Cellular Therapy Department La Conception University Hospital of Marseille  Marseille 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