{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:15:03Z","timestamp":1791342903344,"version":"4.3.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T00:00:00Z","timestamp":1694390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>The Danish national haemoglobinopathy screening programme seeks to determine parental haemoglobinopathy carrier state antenatally. In this retrospective register\u2010based study, we evaluated the 16\u2010year trajectory of this programme, utilising the Danish Red Blood Cell Centre's laboratory database, covering approximately 77% of the Danish population. During the study period, we observed a substantial increase in annual diagnostic examinations performed, from 389 in 2007 to 3030 in 2022. Women constituted 88% of these cases, aligning with the emphasis of the screening programme. Of these, 54% of women of reproductive age (15\u201340\u2009years) and 10% of women &gt;40\u2009years were specified as pregnant. During our study period, 61 children were born with a severe haemoglobinopathy, out of which 23 children were born from mothers not residing in Denmark during their first trimester thus not included in the screening programme. Prenatal invasive testing was performed for 60 fetuses, identifying 12 with homozygous or compound heterozygous haemoglobinopathy. The Danish haemoglobinopathy screening programme has provided screening, information and reproductive choices for numerous families. During the study period, screening for haemoglobinopathies has been steadily increasing and is expected to continue to increase. Awareness of and adherence to the screening programme is subject of further investigation and optimisation.<\/jats:p>","DOI":"10.1111\/bjh.19103","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T07:06:52Z","timestamp":1694416012000},"page":"329-336","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The Danish national haemoglobinopathy screening programme: Report from 16\u2009years of screening in a low\u2010prevalence, non\u2010endemic region"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5458-1416","authenticated-orcid":false,"given":"Esther Agnethe Ejskj\u00e6r","family":"Gravholt","sequence":"first","affiliation":[{"name":"Danish Red Blood Cell Centre, Department of Haematology Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6116-5114","authenticated-orcid":false,"given":"Jesper","family":"Petersen","sequence":"additional","affiliation":[{"name":"Danish Red Blood Cell Centre, Department of Haematology Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8736-2618","authenticated-orcid":false,"given":"Mathis","family":"Mottelson","sequence":"additional","affiliation":[{"name":"Danish Red Blood Cell Centre, Department of Haematology Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5256-7330","authenticated-orcid":false,"given":"Amina","family":"Nardo\u2010Marino","sequence":"additional","affiliation":[{"name":"Danish Red Blood Cell Centre, Department of Haematology Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7533-3112","authenticated-orcid":false,"given":"Mathias","family":"Rathe","sequence":"additional","affiliation":[{"name":"Hans Christian Andersen Children's Hospital Odense University Hospital  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1724-0838","authenticated-orcid":false,"given":"Marianne","family":"Olsen","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2278-2384","authenticated-orcid":false,"given":"Charlotte","family":"Holm","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics Copenhagen University Hospital \u2013 Amager and Hvidovre  Hvidovre Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1592-5407","authenticated-orcid":false,"given":"Finn Stener","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics Copenhagen University Hospital \u2013 Amager and Hvidovre  Hvidovre Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Fetal Medicine Unit, Department of Gynaecology and Obstetrics Copenhagen University Hospital \u2013 Amager and Hvidovre  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Birgens","sequence":"additional","affiliation":[{"name":"Danish Red Blood Cell Centre, Department of Haematology Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2082-0738","authenticated-orcid":false,"given":"Andreas","family":"Glenth\u00f8j","sequence":"additional","affiliation":[{"name":"Danish Red Blood Cell Centre, Department of Haematology Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.06.036673"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003327"},{"key":"e_1_2_11_4_1","unstructured":"World Health Organization.Thalassaemias and other haemoglobinopathies \u2013 Report by the Secretariat[Internet].2006:1\u20138. [cited 2022 Feb 10]. Available from:https:\/\/apps.who.int\/gb\/archive\/pdf_files\/EB118\/B118_5\u2010en.pdf"},{"key":"e_1_2_11_5_1","unstructured":"The National Integration Barometer.Hvor mange og hvem er indvandrere i Danmark?[How Many and Who Are Immigrants in Denmark] [Internet]. 2022 [cited 2022 Oct 4]. Available from:https:\/\/integrationsbarometer.dk\/tal\u2010og\u2010analyser\/INTEGRATION\u2010STATUS\u2010OG\u2010UDVIKLING"},{"key":"e_1_2_11_6_1","unstructured":"Statistics Denmark.Indvandrere i Danmark 2022 [Immigrants in Denmark 2022] [Internet]. 2022. 172 p. [cited 2023 Jan 11]. Available from:https:\/\/www.dst.dk\/Site\/Dst\/Udgivelser\/GetPubFile.aspx?id=29447&sid=indv2020"},{"key":"e_1_2_11_7_1","unstructured":"www.DFMS.dk.Dansk F\u00f8talmedicinsk Database (F\u00d8TO\u2010databasen) [The Danish Fetal Medicine Database] [Internet]. 2018:1\u201362. [cited 2022 Sep 25]. Available from:https:\/\/static1.squarespace.com\/static\/5d8120d60fe9717b4299a867\/t\/5f22a74d4bd7ac5016728a9c\/1596106589853\/2020\u201003\u201018+\u00c5rsrapport_F\u00d8TO_2018_officiel.pdf"},{"key":"e_1_2_11_8_1","unstructured":"Statistics Denmark. Births [Internet]. [cited 2023 Jun 12]. Available from:https:\/\/www.dst.dk\/en\/Statistik\/emner\/borgere\/befolkning\/foedsler"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genom-091416-035451"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15600"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a011775"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/03630269.2018.1528986"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16188"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-553X.2006.00836.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30202"},{"key":"e_1_2_11_16_1","unstructured":"Public Health England.NHS Sickle Cell and Thalassaemia Screening Programme Data Report 2016 to 2017: Trends and Performance Analysis [Internet]. 2018:1\u201346. [cited 2022 Oct 12].\u00a0Available from:https:\/\/assets.publishing.service.gov.uk\/government\/uploads\/system\/uploads\/attachment_data\/file\/713120\/SCT_data_report_2016_to_2017.pdf"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2019-206317"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41431-022-01156-0"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201013751\u20108"},{"key":"e_1_2_11_20_1","unstructured":"Danish Health Authority.Anbefalinger for svangreomsorgen 2022 [Recommendations for Pregnancy Care 2022]. Sundhedsstyrelsen [Internet]. 2021;3(1). [cited 2022 Sep 25]. Available from:https:\/\/www.sst.dk\/da\/udgivelser\/2022\/anbefalinger\u2010for\u2010svangreomsorgen"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31822-6"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15820"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15596"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21408"},{"key":"e_1_2_11_25_1","unstructured":"FINOSE.Zynteglo (Autologous CD34+ Cells Encoding \u03b2A\u2010T87Q\u2010Globin Gene) [Internet]. 2019. [cited 2023 Mar 21]. Available from:https:\/\/www.fimea.fi\/documents\/160140\/1454401\/FINOSE+joint+assessment+report+Zynteglo+FINAL.pdf\/1a1d3dc5\u2010db79\u201048c8\u20106622\u2010cff9b04ce088?t=1589197458993"},{"key":"e_1_2_11_26_1","unstructured":"HvasA\u2010M EhlersL M\u00f8llerHJ Danmark Sundhedsstyrelsen Monitorering & Medicinsk Teknologivurdering.Screening af gravide indvandrere for h\u00e6moglobinopati: en medicinsk teknologivurdering [Screening of pregnant immigrants \u2013 a medicinal technology assesment. Abstract page 10\u201312]. Vol. 9. 2009."},{"key":"e_1_2_11_27_1","unstructured":"Statistics Denmark.Statistikbanken [Statistics Denmark]. [Internet]. [cited 2023 Mar 8]. Available from:https:\/\/www.dst.dk\/da\/"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S250251"},{"issue":"3","key":"e_1_2_11_29_1","first-page":"1","article-title":"Det danske screenings program for h\u00e6moglobinopatier","volume":"183","author":"Glenth\u00f8j A","year":"2021","journal-title":"Ugeskr Laeger"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.1.360"},{"issue":"25","key":"e_1_2_11_31_1","first-page":"3934","article-title":"Hemoglobinopathy in the county of Copenhagen","volume":"159","author":"Birgens HS","year":"1997","journal-title":"Ugeskr Laeger"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001484"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.19103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T06:57:15Z","timestamp":1760079435000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.19103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,11]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/bjh.19103"],"URL":"https:\/\/doi.org\/10.1111\/bjh.19103","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,11]]},"assertion":[{"value":"2023-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}