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Combining VEN with hypomethylating agents (HMAs) has shown impressive response rates in high\u2010risk myelodysplastic syndromes (MDS) and relapsed\/refractory AML. However, the efficacy of VEN and HMAs in treating <jats:italic>DDX41<\/jats:italic>\u2010mutated (m<jats:italic>DDX41<\/jats:italic>) MDS\/AML patients remains uncertain. Despite the favourable prognostic nature of m<jats:italic>DDX41<\/jats:italic> MDS\/AML patients, there is a lack of clinical experience regarding their response to different treatment regimens, leading to an unknown optimal therapeutic approach.<\/jats:p>","DOI":"10.1111\/bjh.19105","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T00:24:59Z","timestamp":1694737499000},"page":"171-176","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Venetoclax plus hypomethylating agents in <scp><i>DDX41<\/i><\/scp>\u2010mutated acute myeloid leukaemia and myelodysplastic syndrome: Mayo Clinic series on 12 patients"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5247-5065","authenticated-orcid":false,"given":"Ahmad","family":"Nanaa","sequence":"first","affiliation":[{"name":"Division of Hematology Mayo Clinic  Rochester Minnesota USA"},{"name":"John H. 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