{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:30:58Z","timestamp":1791477058110,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018170","name":"Fondation Pierre Fabre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018170","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Sickle cell disease (SCD) is a life\u2010threatening disease requiring reliable early diagnosis. We assessed the acceptability and diagnostic performances of two rapid diagnostic tests (RDTs) to identify SCD (HbSS, HbSC, HbS\/\u03b2\u2010thalassaemia) or SCD carrier (HbS\/HbC) in a pilot SCD newborn screening (NBS) strategy in Mali. All consenting delivering women were offered SCD NBS using cord blood sampling on two RDTs (SickleScan\u00ae and HemotypeSC\u00ae) compared to the high\u2010performance liquid chromatography (HPLC) gold standard to detect SCD states. From April 2021 to August 2021, 4333 delivering women were eligible of whom 96.1% were offered NBS: 1.6% refused, 13.8% delivered before consenting and 84.6% consented; 3648 newborns were diagnosed by HPLC; 1.64% had SCD (0.63% HbSS, 0.85% HbSC, 0.16 HbS\/\u03b2\u2010plus\u2010thalassaemia); 21.79% were SCD carrier. To detect accurately SCD, SickleScan\u00ae had a sensitivity of 81.67% (95% confidence interval [CI]: 71.88\u201391.46) and a negative predictive value (NPV) of 99.69% (95% CI: 99.51\u201399.87); HemotypeSC\u00ae had a sensitivity of 78.33% (95% CI: 67.91\u201388.76) and a NPV of 99.64% (95% CI: 99.44\u201399.83). To detect SCD carrier: SickleScan\u00ae sensitivity was 96.10% (95% CI: 94.75\u201397.45) and NPV, 98.90% (95% CI: 98.51\u201399.29); HemotypeSC\u00ae sensitivity was 95.22% (95% CI: 93.74\u201396.70) and NPV, 98.66% (95% CI: 98.24\u201399.03). Routine SCD NBS was acceptable. Compared with HPLC, both RDTs had reliable diagnostic performances to exclude SCD\u2010free newborns and to identify SCD carriers to be further confirmed. This strategy could be implemented in large\u2010scale NBS programmes.<\/jats:p>","DOI":"10.1111\/bjh.19108","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T07:35:08Z","timestamp":1695195308000},"page":"337-345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Potential for a <scp>large\u2010scale<\/scp> newborn screening strategy for sickle cell disease in Mali: A comparative diagnostic performance study of two rapid diagnostic tests (<scp>SickleScan<\/scp>\u00ae and <scp>HemotypeSC<\/scp>\u00ae) on cord blood"],"prefix":"10.1111","volume":"204","author":[{"given":"Aldiouma","family":"Guindo","sequence":"first","affiliation":[{"name":"Centre de Recherche et Lutte contre la Dr\u00e9panocytose (CRLD)  Bamako Mali"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zenab","family":"Cisse","sequence":"additional","affiliation":[{"name":"CERPOP, UMR 1295, INSERM 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