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We conducted a prospective, non\u2010comparative, single\u2010centre study to determine whether famotidine, a H2 receptor antagonist, reduces P\u2010selectin expression in SCD children. The median plasma P\u2010selectin level was significantly reduced after 29\u2009days of oral famotidine (53.2\u2009ng\/mL [IQR: 46.7\u201363.4] vs. 69.9\u2009ng\/mL [IQR: 53.6\u201384.2], median difference \u221210.2\u2009ng\/mL [IQR: \u221221.8 to \u22122.7], <jats:italic>p<\/jats:italic>\u2009=\u20090.005) in 28 patients. No effect was observed on other adhesion molecules, inflammation or haemolysis markers, except decreased reticulocyte count. No adverse events deemed related to famotidine were observed. Randomized controlled trials are now needed to assess the efficacy of famotidine in preventing vaso\u2010occlusion in SCD.<\/jats:p>","DOI":"10.1111\/bjh.19111","type":"journal-article","created":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T19:04:56Z","timestamp":1695063896000},"page":"346-351","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Oral famotidine reduces the plasma level of soluble P\u2010selectin in children with sickle cell disease"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7068-4530","authenticated-orcid":false,"given":"Slimane","family":"Allali","sequence":"first","affiliation":[{"name":"Department of General Paediatrics and Paediatric Infectious Diseases, Sickle Cell Centre, Assistance Publique \u2013 H\u00f4pitaux de Paris (AP\u2010HP) Necker\u2010Enfants Malades Hospital, Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Laboratory of Cellular and Molecular Mechanisms of Haematological Disorders and Therapeutical Implications, Imagine Institute, Inserm U1163 Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Laboratory of Excellence GR\u2010Ex  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabienne","family":"Marquant","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche Clinique\/Centre d'investigation Clinique Necker\u2010Enfants Malades Hospital, AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Rignault\u2010Bricard","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular and Molecular Mechanisms of Haematological Disorders and Therapeutical Implications, Imagine Institute, Inserm U1163 Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of General Paediatrics and Paediatric Infectious Diseases, Sickle Cell Centre, Assistance Publique \u2013 H\u00f4pitaux de Paris (AP\u2010HP) Necker\u2010Enfants Malades Hospital, Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Laboratory of Excellence GR\u2010Ex  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9phine","family":"Brice","sequence":"additional","affiliation":[{"name":"Department of General Paediatrics and Paediatric Infectious Diseases, Sickle Cell Centre, Assistance Publique \u2013 H\u00f4pitaux de Paris (AP\u2010HP) Necker\u2010Enfants Malades Hospital, Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Laboratory of Excellence GR\u2010Ex  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariane","family":"de Montalembert","sequence":"additional","affiliation":[{"name":"Department of General Paediatrics and Paediatric Infectious Diseases, Sickle Cell Centre, Assistance Publique \u2013 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