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It is often poor compared with other chronic medical conditions or measured as a multidomain disease\u2010specific construct. We previously reported outcomes in the Start Healing in Patients with Hydroxyurea (SHIP\u2010HU) randomized controlled trial in adolescents and adults with SCD at six clinical sites. Besides the primary outcomes, we also measured HRQoL as a secondary outcome. Patients in the intervention arm were each assigned community health workers (CHWs) who provided case management services. CHW services were independent of medical management, and medical managers were blinded to the study arm. Patients in the control arm received only standard of care. We hypothesized that having a CHW would improve HRQoL in patients enrolled in SHIP\u2010HU. We did not find significant differences between domains of HRQoL in the two study arms. Possible explanations include selection bias of enrolled versus unenrolled patients, selection bias of sites, medical providers and medical management, enforced blinding, and a lack of cooperation between medical managers and CHWs. The importance of CHWs and HRQoL is nonetheless recognized based on the literature. Future interventions on HRQoL in SCD should consider alternative study designs and multimodal interventions.<\/jats:p>","DOI":"10.1111\/bjh.19113","type":"journal-article","created":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T04:25:10Z","timestamp":1696220710000},"page":"649-657","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of community health workers on quality of life in adolescents and young adults with sickle cell disease: The <scp>SHIP\u2010HU<\/scp> study"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6018-5620","authenticated-orcid":false,"given":"India","family":"Sisler","sequence":"first","affiliation":[{"name":"Department of Pediatrics Children's Hospital of Richmond at VCU  Richmond Virigina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna K.","family":"McClish","sequence":"additional","affiliation":[{"name":"Health Care 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