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Posaconazole drug\u2010level monitoring is critical to ensuring adequate mould prophylaxis. A retrospective audit of 99 patients at a tertiary cancer centre, with myeloid malignancies co\u2010prescribed venetoclax and posaconazole between January 2018 and April 2022, was undertaken to evaluate the adequacy of posaconazole prescribing and the rate of breakthrough IFI. Seventy\u2010six patients (77%) had at least one posaconazole level measured in the study period, with 37% requiring a dose adjustment based on steady\u2010state trough levels. Breakthrough IFI occurred in 4% of patients, typically within 1\u2009month of commencing anti\u2010mould prophylaxis. Close monitoring of posaconazole levels in venetoclax\u2010treated patients, particularly in the early, outpatient setting, is critical.<\/jats:p>","DOI":"10.1111\/bjh.19116","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T01:43:21Z","timestamp":1695260601000},"page":"593-598","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Invasive fungal infection following venetoclax and posaconazole co\u2010administration"],"prefix":"10.1111","volume":"203","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9561-3592","authenticated-orcid":false,"given":"Gemma","family":"Reynolds","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Austin Health  Heidelberg Victoria Australia"},{"name":"National Centre for Infections in Cancer Peter MacCallum Cancer Centre  Parkville Victoria 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