{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:32:38Z","timestamp":1791415958506,"version":"4.3.3"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T00:00:00Z","timestamp":1696550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>In this retrospective cohort study of singleton pregnancies in people with sickle cell disease (SCD) delivered at two academic centres between 1990 and 2021, we collected demographic and SCD\u2010related data, pregnancy outcomes, and the highest systolic and diastolic blood pressure (SBP and DBP) at seven time periods. We compared blood pressure values and trajectories in the composite cohort and in each genotype group to control values in a non\u2010SCD pregnancy dataset. There were 290 pregnancies among 197 patients with SCD. Sixteen per cent (<jats:italic>n<\/jats:italic>\u2009=\u200947) of pregnancies had a hypertensive disorder of pregnancy (HDP); the rates did not differ by genotype. The mean SBP and DBP were lower in the HbSS\/HbS\u03b2<jats:sup>0<\/jats:sup> group than in the non\u2010SCD control group at all timepoints. Mean SBP and DBP trajectories were similar between the HbSS\/HbS\u03b2<jats:sup>0<\/jats:sup> group and non\u2010SCD controls, whereas the mean SBP and DBP in the HbSC\/HbS\u03b2<jats:sup>+<\/jats:sup> group decreased between the first and second trimesters and plateaued between the second and third trimesters. There were no differences in blood pressure trajectory by haemoglobin &gt;\/&lt;\u200910\u2009gm\/dL or by chronic transfusion status. Overall, pregnant people with SCD have lower blood pressure than unaffected pregnant people, raising the possibility that HDP are underdiagnosed, particularly in people with HbSS\/HbS\u03b2<jats:sup>0<\/jats:sup>.<\/jats:p>","DOI":"10.1111\/bjh.19133","type":"journal-article","created":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T07:20:52Z","timestamp":1696663252000},"page":"658-667","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Natural history of blood pressure in sickle cell disease pregnancy"],"prefix":"10.1111","volume":"204","author":[{"given":"Macy L.","family":"Early","sequence":"first","affiliation":[{"name":"Division of Hematology, Department of Medicine Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Luo","sequence":"additional","affiliation":[{"name":"Bloomberg School of Public Health Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa","family":"Solow","sequence":"additional","affiliation":[{"name":"Division of Haematology, Department of Medicine University Health Network  Toronto Ontario Canada"},{"name":"Department of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Matusiak","sequence":"additional","affiliation":[{"name":"Division of Haematology, Department of Medicine University Health Network  Toronto Ontario Canada"},{"name":"Department of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahizechukwu C.","family":"Eke","sequence":"additional","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine &amp; Clinical Pharmacology  Baltimore Maryland USA"},{"name":"Department of Gynecology and Obstetrics Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Shehata","sequence":"additional","affiliation":[{"name":"Division of Hematology, Sinai Health System, Department of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phyllis","family":"August","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6744-9238","authenticated-orcid":false,"given":"Kevin H. 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