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In this well\u2010conducted retrospective study, Reynolds et al. suggest that the use of posaconazole prophylaxis in association with venetoclax plus hypomethylating agents or chemotherapy leads to a reduction of IFI incidence. Therapeutic drug monitoring of posaconazole levels is suggested, even if no correlation with IFI risk has been demonstrated.<\/jats:p><jats:p>Commentary on: Reynolds et al. Invasive fungal  infection following venetoclax and posaconazole co\u2010administration. 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