{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T13:26:35Z","timestamp":1792416395413,"version":"4.4.0"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:00:00Z","timestamp":1697068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000374","name":"British Medical Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Regulatory B (Breg) cells are potentially implicated in the pathogenesis of immune thrombocytopenia (ITP). We analysed a prospective cohort of newly diagnosed steroid na\u00efve ITP patients enrolled in the multicentre FLIGHT trial and found that the numbers of Bregs in their peripheral blood were similar to healthy controls. In contrast, Breg numbers were significantly reduced in ITP patients treated with systemic immunosuppression (glucocorticoids or mycophenolate mofetil). We also demonstrate that glucocorticoid treatment impairs Breg interleukin\u201010 production via an indirect T\u2010cell\u2010mediated mechanism.<\/jats:p>","DOI":"10.1111\/bjh.19144","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T06:54:31Z","timestamp":1697093671000},"page":"644-648","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Systemic immunosuppression depletes peripheral blood regulatory B cells in patients with immune thrombocytopenia"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0256-1701","authenticated-orcid":false,"given":"Madeleine L.","family":"Stimpson","sequence":"first","affiliation":[{"name":"Translational Health Sciences University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0478-508X","authenticated-orcid":false,"given":"Julia","family":"Wolf","sequence":"additional","affiliation":[{"name":"University Hospitals Bristol NHS Foundation Trust  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5478-482X","authenticated-orcid":false,"given":"Bruno","family":"Charbit","sequence":"additional","affiliation":[{"name":"Translational Health Sciences University of Bristol  Bristol UK"},{"name":"Institute of Ophthalmology University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3506-9668","authenticated-orcid":false,"given":"Emily L.","family":"Williams","sequence":"additional","affiliation":[{"name":"Translational Health Sciences University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippa J. 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