{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T14:57:12Z","timestamp":1786805832721,"version":"build-2736575974"},"reference-count":6,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Obinutuzumab is a third\u2010generation anti\u2010CD20 monoclonal antibody widely used in the treatment of B\u2010lymphoproliferative disorders but infrequently associated with severe thrombocytopenia, which can be life\u2010threatening. The pathophysiology is unclear, but platelet clearance can be extremely rapid (usually within 24\u2009h). In a retrospective case series, we have identified four cases among 149 recipients of obinutuzumab\u2010containing chemotherapy regimens between 2015 and 2022 treated for haematological malignancies in Canberra, Australia (frequency 2.7%). We illustrate four cases of obinutuzumab\u2010induced thrombocytopenia with a review of the literature. Research is required to identify the pathophysiology and improve early recognition and management of the condition in the context of multiagent chemotherapy.<\/jats:p>","DOI":"10.1111\/bjh.19147","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T04:25:49Z","timestamp":1697689549000},"page":"668-672","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Frequency and outcomes of obinutuzumab\u2010induced thrombocytopenia"],"prefix":"10.1111","volume":"203","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7995-4696","authenticated-orcid":false,"given":"Jun Yen","family":"Ng","sequence":"first","affiliation":[{"name":"Department of Haematology The Canberra Hospital  Canberra Australian Capital Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maansi","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Haematology The Canberra Hospital  Canberra Australian Capital Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9340-8125","authenticated-orcid":false,"given":"Philip","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Haematology The Canberra Hospital  Canberra Australian Capital Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,18]]},"reference":[{"issue":"11","key":"e_1_2_10_2_1","first-page":"1616","article-title":"Acute thrombocytopenia after obinutuzumab administration in a patient with relapsed follicular lymphoma","volume":"61","author":"Sakai K","year":"2020","journal-title":"Rinsho Ketsueki"},{"issue":"1","key":"e_1_2_10_3_1","first-page":"11926","article-title":"Obinutuzumab induced ITP: a case report","volume":"140","author":"Hm A","year":"2022","journal-title":"Blood"},{"key":"e_1_2_10_4_1","unstructured":"Cancer Institute NSW.eviQ Cancer Treatments Online [Internet]. 2022 [cited 2022 Oct 9]. Available from:https:\/\/www.eviq.org.au\/"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.9628-17"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/HS9.0000000000000751"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18826"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.19147","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T06:28:17Z","timestamp":1721197697000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.19147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,18]]},"references-count":6,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1111\/bjh.19147"],"URL":"https:\/\/doi.org\/10.1111\/bjh.19147","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,18]]},"assertion":[{"value":"2023-08-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}