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In this retrospective single\u2010centre study, we determined progression\u2010free survival (PFS) and overall survival (OS) from anti\u2010BCMA failure in 45 QCE patients. Seven (16%) patients received antibody\u2010drug conjugate, 20 (44%) bispecific antibodies and 18 (40%) CAR\u2010T cell. Thirty patients (67%) received \u22651 subsequent line of treatment. PFS was 4.4\u2009months (95% CI\u2009=\u20092.4\u201312.5) and OS 6.3\u2009months (95% CI\u2009=\u20093.9\u201314.4). Having an adverse prognosis, QCE myeloma patients remain an unmet medical need.<\/jats:p>","DOI":"10.1111\/bjh.19148","type":"journal-article","created":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T00:34:35Z","timestamp":1697243675000},"page":"186-190","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Quad\u2010class exposed\/refractory myeloma is associated with short survival"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7960-7330","authenticated-orcid":false,"given":"B\u00e9n\u00e9dicte","family":"Piron","sequence":"first","affiliation":[{"name":"Department of Hematology University Hospital  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domitille","family":"Costes\u2010Tertrais","sequence":"additional","affiliation":[{"name":"Department of Hematology University Hospital  Nantes 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