{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:18:24Z","timestamp":1791584304412,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The success of CD19 Chimeric antigen receptor (CAR) T\u2010cell therapy in large B\u2010cell lymphoma (LBCL) has been partially offset by toxicity and logistical challenges, which off\u2010the\u2010shelf agents like CD20xCD3 bispecific antibodies might potentially overcome. However, when using CAR T outcomes as the \u02bdstandard\u2010of\u2010care comparator\u0315 for relapsed\/refractory (r\/r) LBCL, a potential learning curve with implementing a novel, complex therapy like CAR T needs to be considered. To address this, we analysed 726 UK patients intended to be treated with CD19 CAR T for r\/r LBCL and compared outcomes between the first year of the national CAR T programme (Era 1; 2019) and the more recent treatment era (Era 2; 2020\u20132022). We identified significant improvements for Era 2 versus Era 1 in dropout rate (17% vs. 27%, <jats:italic>p<\/jats:italic>\u2009=\u20090.001), progression\u2010free survival (1\u2010year PFS 50% vs. 32%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and overall survival (1\u2010year OS 60% vs. 40%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). We also observed increased use of bridging therapy, improvement in bridging outcomes, more tocilizumab\/corticosteroid use, reduced high\u2010grade cytokine release syndrome (4% vs. 9%, <jats:italic>p<\/jats:italic>\u2009=\u20090.01) and intensive care unit admissions (20% vs. 32%, <jats:italic>p<\/jats:italic>\u2009=\u20090.001). Our results demonstrate significant improvement in CAR T outcomes over time, highlighting the importance of using up\u2010to\u2010date clinical data when comparing CAR T against new treatment options for r\/r LBCL.<\/jats:p>","DOI":"10.1111\/bjh.19157","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T01:58:40Z","timestamp":1697594320000},"page":"507-513","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Improved outcomes of large B\u2010cell lymphoma patients treated with <scp>CD19 CAR<\/scp> T in the <scp>UK<\/scp> over time"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3138-4815","authenticated-orcid":false,"given":"S.","family":"Boyle","sequence":"first","affiliation":[{"name":"Department of Haematology King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4901-5858","authenticated-orcid":false,"given":"C.","family":"Roddie","sequence":"additional","affiliation":[{"name":"Department of Haematology University College London Hospitals  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"O'Reilly","sequence":"additional","affiliation":[{"name":"Department of Haematology University College London Hospitals  London UK"},{"name":"Department of Haematology UCL Cancer Institute, University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3289-2344","authenticated-orcid":false,"given":"T.","family":"Menne","sequence":"additional","affiliation":[{"name":"Department of Haematology Freeman Hospital  Newcastle UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Norman","sequence":"additional","affiliation":[{"name":"Department of Haematology Manchester Royal Infirmary  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gibb","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology The Christie Hospital  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3007-8303","authenticated-orcid":false,"given":"S.","family":"Lugthart","sequence":"additional","affiliation":[{"name":"Department of Haematology University Hospitals Bristol and Weston  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Chaganti","sequence":"additional","affiliation":[{"name":"Department of Haematology Queen Elizabeth Hospital  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4988-309X","authenticated-orcid":false,"given":"C.","family":"Gonzalez\u00a0Arias","sequence":"additional","affiliation":[{"name":"Department of Haematology Royal Marsden Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Haematology University Hospital of Wales  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Latif","sequence":"additional","affiliation":[{"name":"Department of Haematology Queen Elizabeth II Hospital  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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