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Two new reports describe different methods and strategies for screening in Mali and Denmark, respectively, and their encouraging results suggest that countries should tailor their screening programmes according to local needs, resources and opportunities.<\/jats:p><jats:p>Commentary on: Guindo et al. Potential for a large\u2010scale newborn screening strategy for sickle cell disease in Mali: a comparative diagnostic performance study of two rapid diagnostic tests (SickleScan\u00ae and HemotypeSC\u00ae) on cord blood. Br J Haematol 2024;204:337\u2013345 and Gravholt et al. The Danish national haemoglobinopathy screening programme: report from 16\u2009years of screening in a low\u2010prevalence, non\u2010endemic region. 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