{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:47:17Z","timestamp":1789015637651,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["20575"],"award-info":[{"award-number":["20575"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Reliable biomarkers for early identification of treatment failure in relapsed\/refractory (r\/r) classical Hodgkin lymphoma (cHL) are lacking. Circulating tumour DNA (ctDNA) profiling has emerged as a powerful predictive and prognostic tool in several haemopoietic and non\u2010haemopoietic malignancies and may guide rational treatment choices in r\/r cHL. To assess the predictive and prognostic value of ctDNA, we performed a retrospective analysis on 55 r\/r cHL patients treated with the bendamustine, gemcitabine and vinorelbine (BEGEV) regimen and additionally evaluated the potential utility of integrating ctDNA with interim [<jats:sup>18<\/jats:sup>F]\u2010FDG positron emission tomography (iPET). Baseline ctDNA genotyping in r\/r cHL mirrored gene mutations and pathways involved in newly diagnosed cHL. We found that baseline ctDNA quantification and serial ctDNA monitoring have prognostic value in r\/r cHL receiving salvage chemotherapy. Lastly, integrating ctDNA quantification with iPET evaluation may improve the early identification of patients at high risk of failing standard salvage therapy, who may benefit from an early switch to immunotherapeutic agents. Collectively, our results support the implementation of non\u2010invasive methods to detect minimal residual disease in recurrent cHL and justify its prospective evaluation in appropriately designed clinical trials.<\/jats:p>","DOI":"10.1111\/bjh.19162","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T05:01:05Z","timestamp":1697691665000},"page":"514-524","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Baseline circulating tumour <scp>DNA<\/scp> and interim <scp>PET<\/scp> predict response in relapsed\/refractory classical Hodgkin lymphoma"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8105-1322","authenticated-orcid":false,"given":"Eleonora","family":"Calabretta","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University, Pieve Emanuele  Milan Italy"},{"name":"Department of Oncology and 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