{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T10:49:57Z","timestamp":1782730197927,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T00:00:00Z","timestamp":1699747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>High\u2010dose melphalan followed by autologous haematopoietic stem cell transplantation is widely used in newly diagnosed multiple myeloma (MM) patients as upfront therapy. However, the safety and efficacy of transplantation in patients with renal insufficiency (RI) are controversial. We followed a multicentre (16 SFGM\u2010TC centres) prospective cohort of 50 newly diagnosed MM patients with a serum creatinine clearance of &lt;40\u2009mL\/min at transplantation. Patients received a recommended dose of melphalan of 140\u2009mg\/m<jats:sup>2<\/jats:sup>. The primary end\u2010point was the non\u2010relapse mortality at Day 100. One death occurred during the first 100\u2009days post\u2010transplant. The median time to neutrophil engraftment was 12\u2009days and to platelet engraftment was 13\u2009days. The haematological response improved in 69% of patients, with best responses from partial response (PR) to very good partial response (VGPR) (10%), from PR to complete response (CR)\/stringent complete response (sCR) (16%), from VGPR to CR\/sCR (39%) and from CR to sCR (2%). At 2\u2009years, the overall survival was 84%, the progression\u2010free survival was 70% and the cumulative incidence of relapse was 20%. The renal response improved in 59% of patients, with the best renal responses post\u2010transplant being minimal (9%), partial (2%) and complete (48%). Autologous transplantation was safe and effective in myeloma patients with RI at transplant.<\/jats:p>","DOI":"10.1111\/bjh.19163","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T05:11:58Z","timestamp":1699852318000},"page":"1450-1458","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Low non\u2010relapse mortality and good haematological and renal responses after autologous haematopoietic stem cell transplantation in multiple myeloma patients with renal insufficiency at transplant: A prospective Soci\u00e9t\u00e9 Francophone de\u00a0Greffe de Moelle\u2010Th\u00e9rapie Cellulaire observational study"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6138-8112","authenticated-orcid":false,"given":"Laurent","family":"Garderet","sequence":"first","affiliation":[{"name":"Service d'H\u00e9matologie, APHP, Hopital Piti\u00e9 Salp\u00eatri\u00e8re Sorbonne Universit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hafida","family":"Ouldjeriouat","sequence":"additional","affiliation":[{"name":"Department of Hematology and Cell Therapy, EHU 1st Novembre 1954 Bir el Djir Usto University Ahmed Benbella 1  Oran Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed\u2010Amine","family":"Bekadja","sequence":"additional","affiliation":[{"name":"Department of Hematology and Cell Therapy, EHU 1st Novembre 1954 Bir el Djir Usto University Ahmed Benbella 1  Oran Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Daguenet","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'H\u00e9matologie Clinique et de Th\u00e9rapie Cellulaire CHU de Saint\u2010Etienne  Saint\u2010Etienne 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