{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:48:09Z","timestamp":1790200089978,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T00:00:00Z","timestamp":1699747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Castleman disease (CD) comprises a group of rare and heterogeneous haematological disorders, including unicentric (UCD) and multicentric (MCD) forms, the latter further subdivided into HHV8\u2010MCD, POEMS\u2010MCD and idiopathic\u2010MCD (iMCD). However, according to the Castleman Disease Collaborative Network guidelines, the diagnosis of CD can only be achieved through collaboration between clinicians and pathologists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We applied these clinical and pathological criteria and implement with clonality testing to a retrospective cohort of 48 adult and paediatric Italian patients diagnosed with reactive lymphadenitis with CD\u2010like histological features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We confirmed the diagnosis of CD in 60% (29\/48) of the cases, including 12 (41%) UCD and 17 (59%; five HHV8\u2010MCD, three POEMS\u2010MCD and nine iMCD) MCD. Of the remaining 19 cases (40%) with multiple lymphadenopathy, 5 (26%) were classified as autoimmune diseases, 1 (5%) as autoimmune lymphoproliferative disorder, 1 (5%) as IgG4\u2010related disease, 11 (83%) as reactive lymphadenitis and 1 (5%) as nodal marginal zone lymphoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study emphasizes the importance of the multidisciplinary approach to reactive lymphadenitis with CD\u2010like features in order to achieve a definitive diagnosis and choose the appropriate treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bjh.19171","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T05:21:32Z","timestamp":1699852892000},"page":"534-547","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The application of a multidisciplinary approach in the diagnosis of Castleman disease and Castleman\u2010like lymphadenopathies: A 20\u2010year retrospective analysis of clinical and pathological features"],"prefix":"10.1111","volume":"204","author":[{"given":"Sabrina","family":"Pelliccia","sequence":"first","affiliation":[{"name":"Haematology Unit, Department of Clinical and Molecular Medicine Sant'Andrea University Hospital, Sapienza University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelina","family":"Rogges","sequence":"additional","affiliation":[{"name":"Pathology Unit, Department of Clinical and Molecular Medicine Sant'Andrea University Hospital, Sapienza University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonello","family":"Cardoni","sequence":"additional","affiliation":[{"name":"Pathology Unit IRCCS Bambino Ges\u00f9 Children's Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Lopez","sequence":"additional","affiliation":[{"name":"Pathology Unit, Department of Clinical and Molecular Medicine Sant'Andrea University Hospital, Sapienza University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esmeralda","family":"Conte","sequence":"additional","affiliation":[{"name":"Haematology Unit, Department of Clinical and Molecular Medicine Sant'Andrea University Hospital, Sapienza University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Laura","family":"Faccini","sequence":"additional","affiliation":[{"name":"Haematology Unit, Department of Clinical and Molecular Medicine Sant'Andrea University Hospital, Sapienza University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"De\u00a0Vito","sequence":"additional","affiliation":[{"name":"Pathology Unit IRCCS Bambino Ges\u00f9 Children's Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Girardi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology and Cell and Gene Therapy IRCCS Bambino Ges\u00f9 Children's Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Pathology Unit Campus Bio\u2010Medico University Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ombretta","family":"Annibali","sequence":"additional","affiliation":[{"name":"Haematology Stem Cell Transplantation Unit Campus Biomedico University Hospital, Campus Bio Medico University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Fratoni","sequence":"additional","affiliation":[{"name":"Surgical Pathology Department Sant' Eugenio Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Remotti","sequence":"additional","affiliation":[{"name":"Pathology Unit Belcolle Hospital  Viterbo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gioia","family":"De\u00a0Angelis","sequence":"additional","affiliation":[{"name":"Haematology Unit Belcolle Hospital  Viterbo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Giordano","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine A.O.U. 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