{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:20:53Z","timestamp":1784542853461,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:00:00Z","timestamp":1699401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:00:00Z","timestamp":1699401600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["226\u20102022\u201000003"],"award-info":[{"award-number":["226\u20102022\u201000003"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["Y23H080018"],"award-info":[{"award-number":["Y23H080018"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ20H080001"],"award-info":[{"award-number":["LQ20H080001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2022C03005"],"award-info":[{"award-number":["2022C03005"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Gilteritinib, a potent FMS\u2010like tyrosine kinase 3 (FLT3) inhibitor, was approved for relapsed\/refractory (R\/R)\n                    <jats:italic>FLT3<\/jats:italic>\n                    \u2010mutated acute myeloid leukaemia (AML) patients but still showed limited efficacy. Here, we retrospectively analysed the efficacy and safety of different gilteritinib\u2010based combination therapies (gilteritinib plus hypomethylating agent and venetoclax, G\u2009+\u2009HMA\u2009+\u2009VEN; gilteritinib plus HMA, G\u2009+\u2009HMA; gilteritinib plus venetoclax, G\u2009+\u2009VEN) in 33 R\/R\n                    <jats:italic>FLT3<\/jats:italic>\n                    \u2010mutated AML patients. The composite complete response (CRc) and modified CRc (mCRc) rates were 66.7% (12\/18) and 88.9% (16\/18) in patients received G\u2009+\u2009HMA\u2009+\u2009VEN, which was higher compared with that in G\u2009+\u2009HMA (CRc: 18.2%, 2\/11; mCRc: 45.5%, 5\/11) or G\u2009+\u2009VEN (CRc: 50.0%, 2\/4; mCRc: 50.0%, 2\/4). The median overall survival (OS) for G\u2009+\u2009HMA\u2009+\u2009VEN, G\u2009+\u2009HMA and G\u2009+\u2009VEN treatment was not reached, 160.0\u2009days and 231.0\u2009days. The median duration of remission (DOR) for G\u2009+\u2009HMA\u2009+\u2009VEN, G\u2009+\u2009HMA and G\u2009+\u2009VEN treatment was not reached, 82.0\u2009days and 77.0\u2009days. Four patients in the G\u2009+\u2009HMA\u2009+\u2009VEN group received alloHSCT after remission exhibited prolonged median DOR. The most common grade 3\/4 adverse events were cytopenia, febrile neutropenia and pulmonary infection; there were no differences among the three groups. In conclusion, our data demonstrated promising response of G\u2009+\u2009HMA\u2009+\u2009VEN combination therapy in R\/R\n                    <jats:italic>FLT3<\/jats:italic>\n                    \u2010mutated AML, and it may be considered an effective therapy bridge to transplantation.\n                  <\/jats:p>","DOI":"10.1111\/bjh.19182","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T17:28:15Z","timestamp":1699464495000},"page":"861-870","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Gilteritinib\u2010based combination therapy in adult relapsed\/refractory\n                    <i>FLT3<\/i>\n                    \u2010mutated acute myeloid leukaemia"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2972-610X","authenticated-orcid":false,"given":"Nianci","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Hematology, the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang PR China"},{"name":"Zhejiang Provincial Key Lab of Hematopoietic Malignancy Zhejiang University  Hangzhou Zhejiang PR China"},{"name":"Zhejiang Provincial Clinical Research Center for Hematological Disorders  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Hematology, the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang PR China"},{"name":"Zhejiang Provincial Key Lab of Hematopoietic Malignancy Zhejiang University  Hangzhou Zhejiang PR China"},{"name":"Zhejiang Provincial Clinical Research Center for Hematological Disorders  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yile","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hematology, the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang PR China"},{"name":"Zhejiang Provincial Key Lab of Hematopoietic Malignancy Zhejiang University  Hangzhou Zhejiang PR China"},{"name":"Zhejiang Provincial Clinical Research Center for Hematological Disorders  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Hematology, the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang PR China"},{"name":"Zhejiang Provincial Key Lab of Hematopoietic Malignancy Zhejiang University  Hangzhou Zhejiang PR China"},{"name":"Zhejiang Provincial Clinical Research Center for Hematological Disorders  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinjun","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Hematology, the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang PR China"},{"name":"Zhejiang Provincial Key Lab of Hematopoietic Malignancy Zhejiang University  Hangzhou Zhejiang PR China"},{"name":"Zhejiang Provincial Clinical Research Center for Hematological Disorders  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiejing","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Hematology, the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang PR China"},{"name":"Zhejiang Provincial Key Lab of Hematopoietic Malignancy Zhejiang University  Hangzhou Zhejiang PR China"},{"name":"Zhejiang Provincial Clinical Research Center for Hematological Disorders  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaixiang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Hematology, the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang PR China"},{"name":"Zhejiang Provincial Key Lab of Hematopoietic Malignancy Zhejiang University  Hangzhou Zhejiang PR China"},{"name":"Zhejiang Provincial Clinical Research Center for Hematological Disorders  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juying","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Hematology, the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang PR China"},{"name":"Zhejiang Provincial Key Lab of Hematopoietic Malignancy Zhejiang University  Hangzhou Zhejiang PR China"},{"name":"Zhejiang Provincial Clinical Research Center for Hematological Disorders  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hematology, the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang PR China"},{"name":"Zhejiang Provincial Key Lab of Hematopoietic Malignancy Zhejiang University  Hangzhou Zhejiang PR China"},{"name":"Zhejiang Provincial Clinical Research Center for Hematological Disorders  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Shou","sequence":"additional","affiliation":[{"name":"Department of Hematology Huzhou Central Hospital  Huzhou Zhejiang PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Huang","sequence":"additional","affiliation":[{"name":"Jinhua People's Hospital  Jinhua Zhejiang PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minchao","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Hematology the First Affiliated Hospital of Jiaxing University  Jiaxing Zhejiang PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Hematology 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5603-4160","authenticated-orcid":false,"given":"Hongyan","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Hematology, the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang PR China"},{"name":"Zhejiang Provincial Key Lab of Hematopoietic Malignancy Zhejiang University  Hangzhou Zhejiang PR China"},{"name":"Zhejiang Provincial Clinical Research Center for Hematological Disorders  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8166-9915","authenticated-orcid":false,"given":"Jie","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Hematology, the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang PR China"},{"name":"Zhejiang Provincial Key Lab of Hematopoietic Malignancy Zhejiang University  Hangzhou Zhejiang PR China"},{"name":"Zhejiang Provincial Clinical Research Center for Hematological Disorders  Hangzhou Zhejiang China"},{"name":"Zhejiang University Cancer Center  Hangzhou Zhejiang PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8360-6395","authenticated-orcid":false,"given":"Huafeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology, the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang PR China"},{"name":"Zhejiang Provincial Key Lab of Hematopoietic Malignancy Zhejiang University  Hangzhou Zhejiang PR China"},{"name":"Zhejiang Provincial Clinical Research Center for Hematological Disorders  Hangzhou Zhejiang China"},{"name":"Zhejiang University Cancer Center  Hangzhou Zhejiang PR 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