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By immunohistochemistry analysis of tissue microarray and pathology slides, we found high UMG1 expression in 20%\u201324% of diffuse large B\u2010cell lymphomas (DLBCLs), including highly aggressive BCL2<jats:sup>high<\/jats:sup> and CD20<jats:sup>low<\/jats:sup> cases. UMG1 membrane expression was also found in DLBCL bone marrow\u2010infiltrating cells and established cell lines. Targeting UMG1 with a novel asymmetric UMG1\/CD3\u03b5\u2010bispecific T\u2010cell engager (BTCE) induced redirected cytotoxicity against DLBCL cells and was synergistic with lenalidomide. We conclude that UMG1\/CD3\u03b5\u2010BTCE is a promising therapeutic for DLBCLs.<\/jats:p>","DOI":"10.1111\/bjh.19183","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T23:15:03Z","timestamp":1700003703000},"page":"555-560","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<scp>UMG1<\/scp>\/<scp>CD3\u03b5\u2010bispecific T\u2010cell<\/scp> engager redirects T\u2010cell cytotoxicity against diffuse large <scp>B\u2010cell<\/scp> lymphoma"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7870-7565","authenticated-orcid":false,"given":"Daniele","family":"Caracciolo","sequence":"first","affiliation":[{"name":"Department of Experimental and Clinical Medicine Magna Gr\u00e6cia University  Catanzaro Italy"},{"name":"Medical and Translational Oncology AOU Renato Dulbecco  Catanzaro 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