{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:07:31Z","timestamp":1789016851449,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:00:00Z","timestamp":1699833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002739","name":"Aarhus Universitets Forskningsfond","doi-asserted-by":"publisher","award":["AUFF\u2010E\u20102017\u20107\u201017"],"award-info":[{"award-number":["AUFF\u2010E\u20102017\u20107\u201017"]}],"id":[{"id":"10.13039\/501100002739","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Standard CHOP treatment includes a high cumulative dose of prednisone, and studies have shown increased fracture risk following CHOP. It is unclear whether reductions in bone mineral density (BMD) are caused by glucocorticoids or by the combination with chemotherapy. Our objective was to determine the effect of obinutuzumab (G)\/rituximab (R)\u2010bendamustine versus G\/R\u2010CHOP on BMD in follicular lymphoma patients. Patients in this GALLIUM post hoc study were \u226560\u2009years old and in complete remission at induction treatment completion (ITC), following treatment with G or R in combination with bendamustine or CHOP. To assess BMD, Hounsfield units (HU) were measured in lumbar vertebra L1 on annual computed tomography. Furthermore, vertebral compression fractures were recorded. Of 173 patients included, 59 (34%) received CHOP and 114 (66%) received bendamustine. At baseline, there was no difference in HU between groups. The mean HU decrease from baseline to ITC was 27.8 after CHOP and 17.3 after bendamustine, corresponding to a difference of 10.4 (95% CI: 3.2\u201317.6). Vertebral fractures were recorded in 5\/59 patients receiving CHOP and in 2\/114 receiving bendamustine. CHOP was associated with a significant greater decrease in BMD and more frequent fractures. These results suggest that prophylaxis against BMD loss should be considered.<\/jats:p>","DOI":"10.1111\/bjh.19194","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T04:21:25Z","timestamp":1699935685000},"page":"1271-1278","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The impact of <scp>CHOP<\/scp> versus bendamustine on bone mineral density in patients with indolent lymphoma enrolled in the <scp>GALLIUM<\/scp> study"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8670-939X","authenticated-orcid":false,"given":"Mette Abildgaard","family":"Pedersen","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine and PET Centre Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Biomedicine Aarhus University  Aarhus Denmark"},{"name":"Steno Diabetes Center Aarhus Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0144-1305","authenticated-orcid":false,"given":"Lars C.","family":"Gormsen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and PET Centre Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lasse H.","family":"Jakobsen","sequence":"additional","affiliation":[{"name":"Department of Hematology, Clinical Cancer Research Center Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6631-9749","authenticated-orcid":false,"given":"Toby A.","family":"Eyre","sequence":"additional","affiliation":[{"name":"Hematology and Cancer Centre Oxford University Hospitals National Health Service (NHS) Foundation Trust  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0996-1812","authenticated-orcid":false,"given":"Marianne T.","family":"Severinsen","sequence":"additional","affiliation":[{"name":"Department of Hematology, Clinical Cancer Research Center Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine, The Faculty of Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8848-4879","authenticated-orcid":false,"given":"Joachim","family":"Baech","sequence":"additional","affiliation":[{"name":"Department of Hematology, Clinical Cancer Research Center Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine, The Faculty of Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7395-7805","authenticated-orcid":false,"given":"Eldad J.","family":"Dann","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Rambam Health Care Campus  Haifa Israel"},{"name":"Ruth and Bruce Rappaport Faculty of Medicine Technion  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Knapp","sequence":"additional","affiliation":[{"name":"F. 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