{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T09:35:57Z","timestamp":1758706557639,"version":"3.40.5"},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:00:00Z","timestamp":1700006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFA0110802"],"award-info":[{"award-number":["2019YFA0110802"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270152","81970121"],"award-info":[{"award-number":["82270152","81970121"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,4]]},"abstract":"Summary<\/jats:title>The coronavirus disease 2019 (COVID\u201019) pandemic has a significant impact on the immune system. This is the first and largest study on pre\u2010existing immune thrombocytopenia (ITP) patients infected with COVID\u201019 in China. We prospectively collected ITP patients infected with COVID\u201019 enrolled in the National Longitudinal Cohort of Hematological Diseases (NICHE, NCT04645199) and followed up for at least 1\u2009month after infection. One thousand and one hundred forty\u2010eight pre\u2010existing ITP patients were included. Two hundred and twelve (18.5%) patients showed a decrease in the platelet (PLT) count after infection. Forty\u2010seven (4.1%) patients were diagnosed with pneumonia. Risk factors for a decrease in the PLT count included baseline PLT count <50\u2009\u00d7\u2009109<\/jats:sup>\/L (OR, 1.76; 95% CI, 1.25\u20132.46; p<\/jats:italic>\u2009=\u20090.001), maintenance therapy including thrombopoietin receptor agonists (TPO\u2010RAs) (OR, 2.27; 95% CI, 1.60\u20133.21; p<\/jats:italic>\u2009<\u20090.001) and previous splenectomy (OR, 1.98; 95% CI, 1.09\u20133.61; p<\/jats:italic>\u2009=\u20090.03). Risk factors for pneumonia included age \u226540\u2009years (OR, 2.45; 95% CI, 1.12\u20135.33; p<\/jats:italic>\u2009=\u20090.02), \u22652 comorbidities (OR, 3.47; 95% CI, 1.63\u20137.64; p<\/jats:italic>\u2009=\u20090.001), maintenance therapy including TPO\u2010RAs (OR, 2.14; 95% CI, 1.17\u20133.91; p<\/jats:italic>\u2009=\u20090.01) and immunosuppressants (OR, 3.05; 95% CI, 1.17\u20137.91; p<\/jats:italic>\u2009=\u20090.02). In this cohort study, we described the characteristics of pre\u2010existing ITP patients infected with COVID\u201019 and identified several factors associated with poor outcomes.<\/jats:p>","DOI":"10.1111\/bjh.19198","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T22:48:05Z","timestamp":1700088485000},"page":"1207-1218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Characteristics and outcomes of COVID<\/scp>\u201019 in Chinese immune thrombocytopenia patients: A prospective cohort study"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7309-8545","authenticated-orcid":false,"given":"Yunfei","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem Institute of Hematology & Blood Diseases Hospital, 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