{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:12:35Z","timestamp":1785881555374,"version":"3.56.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004328","name":"Genentech","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004328","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Outcome data of patients with relapsed\/refractory (R\/R) diffuse large B\u2010cell lymphoma (DLBCL) beyond the second line are scarce outside of clinical trials. Novel therapies in the R\/R setting have been approved based on single\u2010arm trials, but results need to be contextualized by real\u2010world outcomes. Medical records from 3753 Danish adults diagnosed with DLBCL were reviewed. Patients previously treated with rituximab and anthracycline\u2010based chemotherapy who received the third or later line (3\u2009L+) of treatment after 1 January 2015, were included. Only 189 patients with a median age of 71\u2009years were eligible. The median time since the last line of therapy was 6\u2009months. Patients were treated with either best supportive care (22%), platinum\u2010based salvage therapy (13%), low\u2010intensity chemotherapy (22%), in clinical trial (14%) or various combination treatments (32%). The 2\u2010year OS\u2010\/PFS estimates were 25% and 12% for all patients and 49% and 17% for those treated with platinum\u2010based salvage therapy. Age \u226570, CNS involvement, elevated LDH and ECOG \u22652 predicted poor outcomes, and patients with 0\u20131 of these risk factors had a 2\u2010year OS estimate of 65%. Only a very small fraction of DLBCL patients received third\u2010line treatment and were eligible for inclusion. Outcomes were generally poor, but better in intensively treated, fit young patients with limited disease.<\/jats:p>","DOI":"10.1111\/bjh.19201","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T18:37:27Z","timestamp":1701110247000},"page":"839-848","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Real\u2010world outcomes following third or subsequent lines of therapy: A Danish population\u2010based study on 189 patients with relapsed\/refractory large B\u2010cell lymphomas"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8739-0421","authenticated-orcid":false,"given":"Ahmed Ludvigsen","family":"AL\u2010Mashhadi","sequence":"first","affiliation":[{"name":"Department of Haematology, Clinical Cancer Research Centre Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"},{"name":"Department of Haematology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6575-7686","authenticated-orcid":false,"given":"Lasse Hjort","family":"Jakobsen","sequence":"additional","affiliation":[{"name":"Department of Haematology, Clinical Cancer Research Centre Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"},{"name":"Department of Mathematical Sciences Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6522-4086","authenticated-orcid":false,"given":"Peter","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Haematology Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Ortved","family":"Gang","sequence":"additional","affiliation":[{"name":"Department of Haematology Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Luise","family":"Thorsteinsson","sequence":"additional","affiliation":[{"name":"Department of Haematology Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaziwa","family":"Rasoul","sequence":"additional","affiliation":[{"name":"Department of Haematology Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith Melchior","family":"Haissman","sequence":"additional","affiliation":[{"name":"Department of Haematology Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Haematology Zealand University Hospital  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Buch","family":"T\u00f8stesen","sequence":"additional","affiliation":[{"name":"Department of Haematology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette Niemann","family":"Christoffersen","sequence":"additional","affiliation":[{"name":"Department of Haematology Odense University Hospital  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Jelicic","sequence":"additional","affiliation":[{"name":"Department of Haematology Vejle Hospital  Vejle Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer B\u00f8gh","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Haematology Section, Goedstrup Hospital  Herning Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troels","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Haematology Section, Goedstrup Hospital  Herning Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andriette","family":"Dessau\u2010Arp","sequence":"additional","affiliation":[{"name":"Department of Haematology Hospital South West Jutland  Esbjerg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas P. 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