{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:46:08Z","timestamp":1747183568177,"version":"3.40.5"},"reference-count":9,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:p>Cattaneo et\u00a0al. report a unique case of a multiple myeloma patient with elevated B\u2010cell maturation antigen (BCMA) surface density, potentially due to genetic alterations in the gamma\u2010secretase protease complex\u2014responsible for BCMA cleavage from plasma cells. No mutations in the BCMA gene were detected, but there was partial deletion of PSEN1 and amplification of PSEN2 (components of the gamma\u2010secretase complex), which may explain the lack of response to the gamma\u2010secretase inhibitor DAPT. This case, along with recent published literature, underscores the significance of gamma secretase in modulating BCMA density and the potential impact of its genetic alterations.<\/jats:p><jats:p>Commentary on: Cattaneo et\u00a0al. Genetic defects of gamma\u2010secretase genes in a multiple myeloma patient with high and dysregulated BCMA surface density: A case report. Br J Haematol 2024;204:571\u2010575.<\/jats:p>","DOI":"10.1111\/bjh.19222","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T14:20:44Z","timestamp":1701181244000},"page":"391-392","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unveiling the link between genetic alterations in gamma secretase and <scp>BCMA<\/scp> surface density in multiple myeloma"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1880-7094","authenticated-orcid":false,"given":"Andrew J.","family":"Cowan","sequence":"first","affiliation":[{"name":"Fred Hutch Cancer Center UW Medicine  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damian J.","family":"Green","sequence":"additional","affiliation":[{"name":"Fred Hutch Cancer Center UW Medicine  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,28]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_2_2_1","DOI":"10.1111\/bjh.19168"},{"doi-asserted-by":"publisher","key":"e_1_2_2_3_1","DOI":"10.1038\/ncomms8333"},{"doi-asserted-by":"publisher","key":"e_1_2_2_4_1","DOI":"10.1016\/S0896-6273(03)00205-8"},{"doi-asserted-by":"publisher","key":"e_1_2_2_5_1","DOI":"10.1136\/jitc-2022-005403"},{"doi-asserted-by":"publisher","key":"e_1_2_2_6_1","DOI":"10.1016\/S1470-2045(23)00246-2"},{"doi-asserted-by":"publisher","key":"e_1_2_2_7_1","DOI":"10.1182\/blood.2019000050"},{"doi-asserted-by":"publisher","key":"e_1_2_2_8_1","DOI":"10.1016\/S0140-6736(21)00933-8"},{"doi-asserted-by":"publisher","key":"e_1_2_2_9_1","DOI":"10.1056\/NEJMoa2024850"},{"doi-asserted-by":"publisher","key":"e_1_2_2_10_1","DOI":"10.1056\/NEJMoa1817226"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.19222","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T06:04:12Z","timestamp":1707285852000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.19222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,28]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/bjh.19222"],"URL":"https:\/\/doi.org\/10.1111\/bjh.19222","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"type":"print","value":"0007-1048"},{"type":"electronic","value":"1365-2141"}],"subject":[],"published":{"date-parts":[[2023,11,28]]},"assertion":[{"value":"2023-11-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}